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" Induced Mutagenesis Molecular Mechanisms and Their Implications for Environmental Protection. "
Lawrence, Christopher W.
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BL
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| Record Number
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721598
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b541305
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| Main Entry
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Lawrence, Christopher W.
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| Title & Author
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Induced Mutagenesis Molecular Mechanisms and Their Implications for Environmental Protection.\ Lawrence, Christopher W.
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| Publication Statement
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Springer Verlag, 2013
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| ISBN
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1468443828
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: 9781468443820
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| Contents
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Session I: Mutagen/DNA Interactions.- Mutagenic effects of nucleic acid modification and repair assessed by in vitro transcription.- Genetic effects of bisulfite: Implications for environmental protection.- Session II: Infidelity and Specificity.- Infidelity of DNA replication as a basis of mutagenesis.- The specificity of infidelity of DNA polymerase.- Replication and mutagenesis of irradiated single-strand phage DNA.- Mutational specificity of UV light: Influence of excision repair and the mutator plasmid pKM101.- Session III: Genetic Analysis of Mutagenesis.- Regulation and function of cellular gene products involved in UV and chemical mutagenesis in E. coli.- Differential sensitivity to certain DNA-damaging treatments, including 8-methoxypsoralen plus 340nm ultraviolet irradiation, between K-12 and B/r strains of Escherichia coli.- The use of DNA-repair deficient mutants of Chinese Hamster ovary cells in studying mutagenesis mechanisms and in testing for environmental mutagens.- Session IV: Mammalian Systems.- Variation in response to mutagens amongst normal and repair-defective human cells.- Relationship between excision repair and the cytotoxic and mutagenic action of chemicals and UV radiation.- The induction of resistance to alkylation damage in mammalian cells.- Induced mutagenesis of simian virus 40 infecting carcinogen-treated monkey cells.- Session V: Human Systems and Environmental Protection.- Analysis of chemically induced mutation in single cell populations.- Adaptability of microbial mutagenicity assays to the study of problems of environmental concern.- Final Discussion.- Participants.
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| LC Classification
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QH465.A1L397 2013
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| Added Entry
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Lawrence, Christopher W.
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