Peripheral benzodiazepine receptor protein expression in cells treated with alcohol and cytokines; a...

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" Peripheral benzodiazepine receptor protein expression in cells treated with alcohol and cytokines; a study on alcoholism "
Niu, Mingmei; Syapin, Peter

Document Type	:	AL
Record Number	:	925731
Doc. No	:	LA3g32089d
Language of Document	:	English
Main Entry	:	Niu, Mingmei; Syapin, Peter
Title & Author	:	Peripheral benzodiazepine receptor protein expression in cells treated with alcohol and cytokines; a study on alcoholism [Article]\ Niu, Mingmei; Syapin, Peter
Title of Periodical	:	Berkeley Scientific Journal
Volume/ Issue Number	:	16/2
Date	:	2012
Abstract	:	Alcoholism is a complex disease that impacts the cnS through tolerance, dependence, brain damage and neurological and cognitive deficits. chronic exposure to ethanol brings neurodegeneration and an increase in the level of an outer mitochondrial membrane protein, called the peripheral benzodiazepine receptor, PBr for short. In this study, western blotting and immunocytochemical methods were used to detect the effects of ethanol and cytokine treatments on astrocytes, astrocytomas, and microglia. Although ethanol seemed to have led to a decrease in PBr in the astrocytes and microglia, it did produce an increase in astrocytomas. Additionally, LPS and cytokine mix seemed to have at least physically altered the appearance of these ethanol-exposed cells.