| Document Type
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BL
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| Record Number
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1007442
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| Doc. No
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b761812
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| Main Entry
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Florence, A. T., (Alexander Taylor)
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| Title & Author
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An introduction to clinical pharmaceutics /\ Alexander T. Florence.
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| Publication Statement
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London ;Chicago :: Pharmaceutical Press,, 2010.
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| Page. NO
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xiii, 179 pages :: illustrations ;; 24 cm
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| ISBN
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0853696918
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: 085369964X
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: 9780853696919
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: 9780853699644
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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1 What is clinical pharmaceutics? ; Introduction ; Physical concepts ; The nature of the dosage form and outcomes ; Quality of effect ; Ingredients in dosage forms and their influence on outcomes ; Conclusion ; References -- 2 Excipients: Not always inert. Introduction ; Usually but not always inert ; E-numbers ; Cross-reactivity ; Dyes used in lymph node identification ; Non-ionic surfactants ; Polyoxyethylene glycols (PEGs) ; Adjuvants as therapeutic substances ; Talc as therapeutic agent and excipient ; Active excipients in multiple therapies ; Conclusions ; References -- 3 Thinking chemically. Introduction ; The chemistry of drugs and clinical pharmaceutics ; Chemical nomenclature ; Surface-active drugs ; Acids and bases ; Structural similarities between drugs ; Cross-reactivity ; Beta-lactam antibiotics and the formation of oligomers ; The bisphosphonates ; Hydrophobic and hydrophilic statins ; Photochemical reactions and photoinduced reactions ; Chelation and tetracyclines ; Sugammedex: a cyclodextrin derivative ; Conclusions ; References -- 4 Looking at formulations. Introduction ; Protein drugs and formulations ; Monoclonal antibodies (MAbs) ; Amphotericin B formulations ; A doxorubicin formulation: Doxil ; A propofol formulation: Diprivan ; Long-acting depot injections ; Raft-producing oral formulations ; Etoposide (Vepesid, VP 16 and etoposide phosphate) ; Paclitaxel ; Eutectic mixtures of local anaesthetics ; Ciclosporin (cyclosporin) ; Lupron Depot; Prostap SR and Prostap 3 ; Zoladex ; Fluoroquinolone eye drops ; Ionsys: lontophoretic transdermal device for fentanyl ; Parenterals ; Chloramphenicol ; Materials used in drug delivery ; Conclusions ; References -- 5 Adverse events and formulations and devices. Introduction ; Dosage form type ; Reactions to impurities ; Abnormal bioavailability, high or low ; Testing for adverse effects ; Nanosystems ; Conclusions ; References -- 6 Paediatric, geriatric and special formulations. Introduction ; Extemporaneous formulations ; Effect of formulation and presentation: a case from the literature ; Extemporaneous formulations and performance ; The elderly and their medication ; Enteral feeding ; Drug interactions with nutrient formulations ; Conclusions ; References -- 7 Generic medicines: Conventional drugs and biologicals. Introduction ; Regulatory statements on generic products ; Generics: A question of quality ; Specific conditions and generics ; Reading and deconstructing the literature on bioequivalence ; Antiretroviral drugs ; Bioequivalence of ophthalmic products ; The case of sevoflurane ; Generic biologicals (biologics) ; Conclusions ; References -- 8 The future: Delivery systems for modem therapeutics ; Introduction ; Personalised medicine and medicines ; Drug delivery and personalised medicines ; Technologies ; Nanotechnoiogy ; Cell-based therapies ; Gene therapy ; Conclusions ; References.
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| Abstract
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This textbook describes a variety of dosage forms and their clinical importance and use. The use and behaviour of dosage forms in different age groups and patient groups will also be considered along with recent developments such as personalised therapies and genomics. It contains relevant examples and clinical case studies.
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| Subject
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Drugs-- Dosage forms, Case studies.
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| Subject
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Drugs-- Dosage forms.
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Pharmaceutical chemistry.
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| Subject
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Drugs-- Dosage forms.
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Pharmaceutical chemistry.
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Technology, Pharmaceutical.
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Chemistry, Pharmaceutical.
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Dosage Forms.
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| Subject
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Drug Compounding.
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| Dewey Classification
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615.19
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| LC Classification
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RM
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| NLM classification
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2010 F-450
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QV 778
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