| Document Type
|
:
|
BL
|
| Record Number
|
:
|
1010896
|
| Doc. No
|
:
|
b765266
|
| Title & Author
|
:
|
In vitro toxicology /\ edited by Shayne Cox Gad.
|
| Edition Statement
|
:
|
2nd ed.
|
| Publication Statement
|
:
|
New York :: Taylor & Francis,, 2000.
|
| Page. NO
|
:
|
1 online resource (ix, 410 pages) :: illustrations
|
| ISBN
|
:
|
0203362810
|
|
|
:
|
: 0367800934
|
|
|
:
|
: 1280047437
|
|
|
:
|
: 1420022733
|
|
|
:
|
: 661004743X
|
|
|
:
|
: 9780203362815
|
|
|
:
|
: 9780367800932
|
|
|
:
|
: 9781280047435
|
|
|
:
|
: 9781420022735
|
|
|
:
|
: 9786610047437
|
|
|
:
|
1560327693
|
|
|
:
|
9781560327691
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and index.
|
| Contents
|
:
|
Introduction -- General principles for In vitro -- Ocular toxicity assessment In vitro toxicology -- In vitro methods to predict skin irritation -- Lethality testing -- In vitro genetic toxicity testing -- Pyrogenicity and muscle irritation -- In vitro models for evaluating developmental toxicity -- Neurotoxicology In vitro -- In vitro assessment of nephrotoxicity -- Primary hepatocyte culture as an In vitro toxicologic system for the liver -- Application of In vitro model systems to study cardiovascular toxicity -- Gastrointestinal toxicology: In vitro test systems -- In vitro immonotoxicology -- Strategy and tactics for employment -- Scientific and regulatory considerations in the development of In vitro techniques in toxicology -- Safety issues in the use of human tissue by In vitro metabolism and toxicology laboratories.
|
| Abstract
|
:
|
Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitron̂ models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.) Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.
|
| Subject
|
:
|
Toxicity testing-- In vitro.
|
| Subject
|
:
|
MEDICAL-- Toxicology.
|
| Subject
|
:
|
Toxicity testing-- In vitro.
|
| Subject
|
:
|
Toxicity Tests-- methods.
|
| Subject
|
:
|
Test toxicité-- Méthode.
|
| Subject
|
:
|
Cells, Cultured-- drug effects.
|
| Subject
|
:
|
Drug Evaluation, Preclinical-- methods.
|
| Subject
|
:
|
Tissue Culture
|
| Subject
|
:
|
Cellules en culture-- action des médicaments et substances chimiques.
|
| Subject
|
:
|
Évaluation préclinique médicament-- Méthode.
|
| Dewey Classification
|
:
|
615.9/07
|
| LC Classification
|
:
|
RA1199.4.I5I53 2000eb
|
| NLM classification
|
:
|
QV 602I354 2000
|
| Added Entry
|
:
|
Gad, Shayne C.,1948-
|