| Document Type
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BL
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| Record Number
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1012117
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| Doc. No
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b766487
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| Main Entry
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Domínguez-Bendala, Juan.
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| Title & Author
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Pancreatic stem cells /\ Juan Domínguez-Bendala.
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| Publication Statement
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New York :: Humana Press,, 2009.
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| Series Statement
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Stem cell biology and regenerative medicine
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| Page. NO
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1 online resource (ix, 154 pages) :: illustrations
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| ISBN
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1607611317
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: 1607611325
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: 9781607611318
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: 9781607611325
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| Bibliographies/Indexes
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Includes bibliographical references (pages 111-150) and index.
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| Contents
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152033_1_En_FM1_Chapter.pdf; 152033_1_En_1_Chapter.pdf; The Pancreas; 1 Introduction; 2 The Ductal System; 3 Vasculature; 4 Innervation; 5 Exocrine Pancreas; 6 Endocrine Pancreas; 7 Glucose Metabolism; 152033_1_En_2_Chapter.pdf; Pancreatic Development; 1 Introduction; 2 Generation of Endoderm/Gut Epithelium; 3 Pancreatic Differentiation; Pdx1; 4 Ductal and Exocrine Specification; 5 Endocrine Specification; Ngn3; Isl1; 6 Beta Cell Differentiation; Arx; 7 The Secondary Transition; Prox1; 8 Do Physical Factors Play a Role in Pancreatic Development?
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3.1 Do New Beta Cells Arise from the Duct/Acinar Tissue?3.2 Do New Beta Cells Arise from the Islet?; 3.3 Do New Islets Arise from the Bone Marrow?; 4 Molecular Mechanisms of Islet Regeneration; 4.1 Reversible Epithelial-to-Mesenchymal Transition; 4.2 Self-Duplication; 4.3 Re-ignition of the Embryonic Developmental Program; 152033_1_En_4_Chapter.pdf; Stem Cell Differentiation: General Approaches; 1 Introduction; 1.1 In Vitro; 1.1.1 Chemical Strategies; 1.1.2 Genetic Manipulation; 1.1.3 Protein Transduction; 1.1.4 Microenvironment; 1.2 In Vivo; 152033_1_En_5_Chapter.pdf.
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3.1 Hematopoietic Bone Marrow and Cord Blood Stem Cells152033_1_En_7_Chapter.pdf; Transdifferentiation; 1 Introduction; 2 Directed Liver Transdifferentiation; 152033_1_En_8_Chapter.pdf; Remaining Challenges and Clinical Perspectives; 1 Introduction; 2 Diabetes and Islet Transplantation; 3 Limitations of Islet Transplantation: Engraftment and Long-Term Function; 4 Limitations of Islet Transplantation: Immunosuppression and Tolerance; 4.1 General Considerations About Islet Rejection; 4.2 Immunology of Stem Cells; 5 Conclusions; 152033_1_En_References.pdf; Anchor 1; 152033_1_En_IDX.pdf.
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Embryonic Stem Cells and Pancreatic Differentiation1 Introduction; 2 Mouse ES Cell Experiments; 2.1 Signal-Driven Approaches; 2.2 Genetic Manipulation; 3 Human ES Cell Differentiation; 3.1 Signal-Driven Approaches; 3.2 Genetic Manipulation; 3.3 Protein Transduction; 152033_1_En_6_Chapter.pdf; Adult Stem Cells and Pancreatic Differentiation; 1 Introduction; 2 Mesenchymal Stem Cells; 2.1 Introduction; 2.2 Signal-Driven Approaches; 2.3 Genetic Manipulation; 2.4 Protein Transduction; 2.5 In Vivo Transplantation of Undifferentiated MSCs; 3 Other Stem Cells.
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FlO2 › HIF-1 a › Notch › Endocrine progenitor cell proliferation ›O2 fl HIF-1 a fl Notch › Endocrine progenitor cell diffeflO2 fl Wnt/beta-catenin fl Exocrine progenitor cell proliferation ›O2 › Wnt/beta-catenin › Exocrine progenitor cell prolifera; 9 Correspondence Between Mouse and Human Pancreatic Development; 152033_1_En_3_Chapter.pdf; Pancreatic Regeneration; 1 Introduction; 2 Models of Regeneration; 2.1 Pregnancy; 2.2 Blood Glucose Levels; 2.3 Obesity; 2.4 Partial Pancreatectomy; 2.5 Duct Ligation; 2.6 Cellophane Wrapping; 2.7 Streptozotocin Treatment; 3 Where Do New Islets Come from?
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| Abstract
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The aim of Pancreatic Stem Cells is to provide a broad overview of an intriguing model of organogenesis (the development of the pancreas) from the perspective of stem cell research. The tangible prospect of devising effective cell therapies for type I diabetes -a disease thus far considered incurable- has stoked a widespread interest in harnessing our knowledge on the basic biology behind the development of this organ. This text is conceived as an all-encompassing guide to explore the many aspects of "regenerative therapies" for the endocrine pancreas, from adult and embryonic stem cells to endogenous regeneration and transdifferentiation. All these themes are built upon an up-to-date discussion on pancreatic ontogeny, which provides a solid background for both basic scientists and health professionals.
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| Subject
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Cytology.
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Developmental biology.
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Diabetes.
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Endocrinology.
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Life sciences.
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Pancreas-- Cytology.
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Pancreas-- Differentiation.
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Regenerative medicine.
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Stem cells-- Therapeutic use.
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Biomédecine.
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Cytology.
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Developmental biology.
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Diabetes.
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Endocrinology.
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Life sciences.
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Pancreas-- Cytology.
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Regenerative medicine.
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SCIENCE-- Life Sciences-- Cell Biology.
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Sciences de la vie.
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Pancreas-- cytology.
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Regenerative Medicine-- methods.
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Stem Cell Transplantation.
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Stem Cells.
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| Dewey Classification
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571.6
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| LC Classification
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QH581.2D66 2009
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| NLM classification
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WI 800
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44.87bcl
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