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" Antisense therapeutics / "
edited by M. Ian Phillips ; foreword by Stanley T. Crooke.
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BL
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| Record Number
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1017537
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b771907
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| Title & Author
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Antisense therapeutics /\ edited by M. Ian Phillips ; foreword by Stanley T. Crooke.
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| Edition Statement
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2nd ed.
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| Publication Statement
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Totowa, N.J. :: Humana Press,, ©2005.
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| Series Statement
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Methods in molecular medicine ;; 106
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| Page. NO
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1 online resource (xii, 327 pages) :: illustrations
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| ISBN
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1280359617
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: 1588292053
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: 1592598544
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: 661035961X
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: 9781280359613
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: 9781588292056
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: 9781592598540
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: 9786610359615
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Antisense therapeutics: a promise waiting to be fulfilled / Ian Phillips -- Antisense inhibition: oligonucleotides, ribozymes and siRNAs / Y. Clare Zhang [and others] -- Local application of antisense for prevention of restenosis / Patrick L. Iversen [and others] -- Antisense therapeutics for hypertension: targeting the renin/angiotensin system / M. Ian Phillips and Birgitta Kimura -- Antisense strategies for the treatment of heart failure / Sian E. Harding, Federica Del Monte, and Roger J. Hajjar -- Clinical studies of antisense oligonucleotides for cancer therapy / Rosanne M. Orr and F. Andrew Dorr -- Antisense therapy in clinical oncology: preclinical and clinical experiences / Ingo Tamm -- Radionucleide/peptide nucleic acid diagnosis and treatment of pancreatic cancer / Eric Wickstrom [and others] -- Suppression of pancreatic and colon cancer cells by antisense K-RNA expression vectors / Kazunori Aoki, Shumpei Ohnami, and Teruhiko Yoshida -- Induction of tumor cell apoptosis and chemosensitization by antisense strategies / Manuel Rieber and Mary Strasberg-Rieber -- Utility of an anti-oncogene ribozymes and antisense oligonucletoides in reversing drug resistance / Tadao Funato -- Transport of antisense across the blood/brain barrier / Laura B. Jaeger and William A. Banks -- Transdermal delivery of antisense oligonucletoides / Rhonda M. Brand and Patrick L. Iversen -- Antisense strategies for redirection of drug metabolism: using paclitaxel as a model / Vikram Arora -- Antisense oligonucletoide treatment of inflammatory bowel diseases / Bruce R. Yacyshyn -- Optimizing electroporation conditions for the intracellular delivery of morpholino antisense oligonucleotides directed against the hepatitis C virus IRES / Ronald Jubin.
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| Abstract
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Announcement of the complete sequencing of the human genome in April 2003 demonstrated the presence of thousands of targets for antisense oligonucleotides and opened the way to hundreds of preclinical animal studies and some 20 ongoing clinical trials. In this second edition of Antisense Therapeutics, a team of leading researchers and clinical scientists demonstrate the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs. Highly practical and disease oriented, Antisense Therapeutics, Second Edition offers not only a primer for a new generation of drug discovery researchers, but also an illuminating exploration of the potential in exploiting RNA inhibition for novel human therapeutics.
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| Subject
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Antisense nucleic acids-- Therapeutic use.
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Antisense nucleic acids-- Therapeutic use.
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| Subject
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MEDICAL-- Pharmacology.
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| Subject
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Oligonucleotides, Antisense-- therapeutic use.
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| Subject
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Oligonucleotides, Antisense-- pharmacology.
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| Dewey Classification
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615/.31
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| LC Classification
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RM666.A564A585 2005
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| NLM classification
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QU 57A6332 2005
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| Added Entry
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Phillips, M. Ian.
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