| Document Type
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BL
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| Record Number
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1018052
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| Doc. No
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b772422
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| Title & Author
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Matrix metalloproteinase inhibitors in cancer therapy /\ edited by Neil J. Clendeninn and Krzysztof Appelt.
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| Publication Statement
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Totowa, N.J. :: Humana Press,, ©2000.
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| Series Statement
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Cancer drug discovery and development
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| Page. NO
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1 online resource (xi, 262 pages) :: illustrations (some color)
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| ISBN
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159259011X
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: 9781592590117
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0896036685
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9780896036680
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Abstract
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The association of matrix metalloproteinases (MMPs)-enzymes that disrupt the body's normal repair functions-with several diseases, including growing and invasive tumors, holds the tantalizing promise that their inhibiton might have therapeutic value. In Matrix Metalloproteinase Inhibitors in Cancer Therapy, cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their company's research effort on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, and efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.
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| Subject
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Antineoplastic agents.
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Cancer-- Chemotherapy.
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Extracellular matrix proteins-- Inhibitors-- Therapeutic use.
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| Subject
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Extracellular matrix proteins.
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Metalloproteinases-- Inhibitors-- Therapeutic use.
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Antineoplastic agents.
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Cancer-- Chemotherapy.
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| Subject
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Extracellular matrix proteins.
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HEALTH FITNESS-- Diseases-- Cancer.
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MEDICAL-- Oncology.
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Metalloendopeptidases-- antagonists inhibitors.
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Metalloendopeptidases-- metabolism.
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| Subject
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Extracellular Matrix-- enzymology.
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| Subject
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Neoplasms-- drug therapy.
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| Dewey Classification
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616.99/4061
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| LC Classification
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RC271.M43M38 2000eb
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| NLM classification
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2000 L-917
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QU 136M4338 2001
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| Added Entry
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Appelt, Krzysztof.
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Clendeninn, Neil J.
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