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" Immunotoxicity testing : "
edited by Rodney R. Dietert.
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BL
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| Record Number
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1019233
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b773603
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| Title & Author
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Immunotoxicity testing : : methods and protocols /\ edited by Rodney R. Dietert.
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| Publication Statement
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New York, N.Y. :: Humana Press,, ©2010.
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| Series Statement
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Methods in molecular biology,; 598
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Springer Protocols
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1 online resource (x, 430 pages) :: illustrations
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| ISBN
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1607614014
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: 9781607614012
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1607614006
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9781607614005
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| Notes
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Title from PDF title page (viewed Dec. 9, 2009).
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Immunotoxicology testing: past and future / Michael I. Luster, G. Frank Gerberick -- Developmental immunotoxicity (DIT): the why, when, and how of DIT testing / Rodney R. Dietert, Jamie DeWitt -- An In vivo tiered approach to test immunosensitization by low molecular weight compounds / Irene S. Ludwig, Lydia M. Kwast, Daniëlle Fiechter, Raymond H. Pieters -- Risk of autoimmune disease: challenges for immunotoxicity testing / Rodney R. Dietert, Janice M. Dietert, Jerrie Gavalchin -- Markers of inflammation / Dori R. Germolec, Rachel P. Frawley, Ellen Evans -- Evaluating macrophages in immunotoxicity testing / John B. Barnett, Kathleen M. Brundage -- Host resistance assays including bacterial challenge models / Florence G. Burleson, Gary R. Burleson -- Viral host resistance studies / Wendy Jo Freebern -- Parasite challenge as host resistance models for immunotoxicity testing / Robert W. Luebke -- Tumor challenges in immunotoxicity testing / Sheung Ng, Kotaro Yoshida, Judith T. Zelikoff -- The T-dependent antibody response to keyhole limpet hemocyanin in Rodents / Lisa M. Plitnick, Danuta J. Herzyk -- The Sheep erythrocyte T-dependent antibody response (TDAR) / Kimber L. White, Deborah L. Musgrove, Ronnetta D. Brown -- The Delayed type hypersensitivity assay using protein and xenogeneic cell antigens / Rodney R. Dietert, Terry L. Bunn, Ji-Eun Lee -- The Cytotoxic T lymphocyte assay for evaluating cell-mediated immune function / Gary R. Burleson, Florence G. Burleson, Rodney R. Dietert -- NK cell assays in immunotoxicity testing / Qing Li.
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The Local lymph node assay and skin sensitization testing / Ian Kimber, Rebecca J. Dearman -- Use of contact hypersensitivity in immunotoxicity testing / Jacques Descotes -- Evaluation of apoptosis in immunotoxicity testing / Mitzi Nagarkatti, Sadiye Amcaoglu Rieder, Dilip Vakharia, Prakash S. Nagarkatti -- Dendritic cells in immunotoxicity testing / Donghong Gao, David A. Lawrence -- Evaluating cytokines in immunotoxicity testing / Emanuela Corsini, Robert V. House -- Flow cytometry in preclinical drug development / Patrick B. Lappin -- Enhanced histopathology evaluation of lymphoid organs / Susan A. Elmore -- Immunotoxicity testing in nonhuman primates / Stephanie Grote-Wessels, Werner Frings, Clifford A. Smith, Gerhard F. Weinbauer -- Fundamentals of clinical immunotoxicology / Robert V. House -- In vivo functional tests for assessing immunotoxicity in birds / Keith A. Grasman -- In vitro testing for direct immunotoxicity: state of the art / D.P. Lankveld, H. Loveren, K.A. Baken, R.J. Vandebriel.
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| Abstract
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Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls. Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology.
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| Subject
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Drugs-- Toxicology.
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Immune system-- Effect of drugs on.
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Immunotoxicology.
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Drugs-- Toxicology.
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Immune system-- Effect of drugs on.
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Immunotoxicology.
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Immunotoxins-- adverse effects.
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Disease Models, Animal.
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Drug Evaluation-- methods.
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Drug-Related Side Effects and Adverse Reactions-- immunology.
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Immunologic Tests-- methods.
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Toxicity Tests-- methods.
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| Dewey Classification
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615
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| LC Classification
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RC582.17
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| NLM classification
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QW 525I335 2010
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W1ME9616J v.598 2010
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| Added Entry
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Dietert, Rodney R.
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