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" Antibiotic optimization : "
edited by Robert C. Owens, Paul G. Ambrose, Charles H. Nightingale.
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BL
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| Record Number
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1022223
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| Doc. No
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b776593
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| Title & Author
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Antibiotic optimization : : concepts and strategies in clinical practice /\ edited by Robert C. Owens, Paul G. Ambrose, Charles H. Nightingale.
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| Publication Statement
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New York :: Marcel Dekker,, ©2005.
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| Series Statement
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Infectious disease and therapy ;; v. 33
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| Page. NO
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xiv, 663 pages :: illustrations ;; 24 cm.
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| ISBN
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082475431X
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: 9780824754310
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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How to create a therapectics committee that is scientificaly and economically sound -- The Public Heath Action Plan to Combat Antimicrobial Resistance and the prevention of antimicrobial resistance in health care settings -- Why appropriate antimicrobial selection is important: focus on outcomes -- Understanding pharmacokinetics and pharmacodynamics: application to the antimicrobial formulary decision process -- Optimization of antibacterial therapy to minimize costs, medication errors, and adverse outcomes -- Basic pharmacoeconomics for the hospital decision makers -- Measuring the attributable costs of resistant infections in hospital settings -- Optimizing antimicrobial use and combating bacterial resistance: benchmarking and beyond -- The role of infection control and hospital epidemiology in the optimization of antibiotic use -- Antimicrobial stewardship initiatives: a programmatic approach to optimizing antimicrobial use -- Role of computer-assisted programs in opimizing the use of antimicrobial agents -- Applications of pharmacodynamic principles: from theory to practice -- The antimicrobial fourmulary: reevaluating parenteral cephalosporins in the context of emerging resistance -- Early discharge strategies: role of transitional therapy programs -- Impact of guidelines on antimicrobial treatment of respiratory tract infections -- Abbreviated courses of antibacterial therapy -- Antibiotic cycling strategies -- Outpatient parenteral antimicrobial therapy: role in optimizing length of hospital stay -- Rational use of antifungals for invasive fungal infections in the institutional setting.
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| Abstract
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"Antimicrobial stewardship," a term coined by Dr. Dale Gerding, applies to the selection of an antimicrobial agent and its appropriate dosage and duration of therapy. In principle, this results in the best clinical outcome in the treatment or prevention of infection, with the least toxicity and, most important, a minimal effect on the development of resistance in the patient and in larger populations, whether in the hospital or the community. The goal of this book is to provide the practicing clinician and the interested administrator with the background, scientific foundation, and practical knowledge required to develop institutional programs that foster good antimicrobial stewardship. The book draws on many recommendations by professional societies and national and international organizations that have recognized the importance of antimicrobial stewardship as a mechanism to prevent antimicrobial resistance. The editors are to be congratulated for assembling an expert group of authors to write the 19 chapters that make up this treatise. The book has two main parts. The initial chapters provide an overview of topics that serve as the foundation of a successful program of antimicrobial stewardship, such as the importance of a pharmacy and therapeutics committee, a program for infection control and hospital epidemiology, and a basic understanding of pharmacoeconomics, pharmacokinetics, and pharmacodynamics. The remainder of the book deals with examples of the application of antimicrobial stewardship. These chapters provide insight into the importance of pharmacodynamic principles, transitional-therapy programs, and the development and implementation of an antimicrobial formulary. The chapters are very well referenced and understandable for readers without expert knowledge of the subject. In general, the references are to articles published up to 2003, with a few from 2004.
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| Subject
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Antibiotics.
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Drug resistance in microorganisms-- Prevention.
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Antibiotiques.
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Micro-organismes-- Résistance aux médicaments.
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Antibiotics.
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Drug resistance in microorganisms-- Prevention.
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Antibiotikum.
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Anti-Bacterial Agents-- administration dosage.
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Anti-Bacterial Agents-- adverse effects.
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Drug Resistance, Microbial.
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| Dewey Classification
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615/.329
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| LC Classification
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RM267.A494 2005
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| NLM classification
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W1IN406HMN v.33 2005
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QV 350A6262 2005
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| Added Entry
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Ambrose, Paul G.
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Nightingale, C. H.
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Owens, Robert C.
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