| Document Type
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BL
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| Record Number
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1027581
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| Doc. No
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b781951
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| Main Entry
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Ohta, Yusuke.
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| Title & Author
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Copper-catalyzed multi-component reactions : : synthesis of nitrogen-containing polycyclic compounds /\ Yusuke Ohta.
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| Publication Statement
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Berlin ;Heidelberg ;New York :: Springer,, ©2011.
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| Series Statement
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Springer theses
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| Page. NO
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1 online resource (xv, 102 pages)
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| ISBN
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3642154727
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: 3642154735
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: 9783642154720
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: 9783642154737
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9783642154720
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| Bibliographies/Indexes
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Includes bibliographical references.
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| Contents
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Copper-Catalyzed Multi-Component Reactions; Supervisor's Foreword; Acknowledgments; Contents; 1 Introduction; References; Part I Synthesis of Indole Derivatives; 2 Construction of 2-(Aminomethyl)indoles Through Copper-Catalyzed Domino Three-Component Coupling and Cyclization; 3 Facile Synthesis of 1,2,3,4-Tetrahydro- beta -Carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic Cyclization; 4 Concise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling-Cyclization-N-Arylation under Microwave Irradiation.
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Part II Synthesis of Isoquinoline Derivatives5 Facile Synthesis of 3-(Aminomethyl)isoquinoline by Copper-Catalyzed Domino Four-Component Coupling and Cyclization; 6 Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four Component Coupling, Cascade Cyclization, and Oxidation; 7 Conclusions.
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| Abstract
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A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline.
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| Subject
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Polycyclic compounds-- Synthesis.
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| Subject
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Chimie.
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| Subject
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Polycyclic compounds-- Synthesis.
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| Subject
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Science des matériaux.
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| Subject
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SCIENCE-- Chemistry-- Organic.
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| Dewey Classification
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547/.2
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| LC Classification
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QD401.O38 2011
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