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" Gene therapy of cancer : "
edited by Wolfgang Walther and Ulrike Stein.
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BL
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| Record Number
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1027669
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b782039
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| Title & Author
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Gene therapy of cancer : : methods and protocols /\ edited by Wolfgang Walther and Ulrike Stein.
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| Edition Statement
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2nd ed.
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| Publication Statement
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New York, NY :: Humana Press,, ©2009.
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| Series Statement
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Methods in molecular biology,; 542
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Springer protocols
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| Page. NO
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1 online resource (xiv, 731 pages) :: illustrations (some color)
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| ISBN
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159745561X
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: 1934115851
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: 9781597455619
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: 9781934115855
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Section 1. Experimental approaches in cancer therapy -- 1. Development of gene therapy / Jean-Pierre Gillet [and others] -- Subsection B -- Vectorology for cancer gene therapy -- 2. Designing adenoviral vectors for tumor-specific targeting / Ramon Alemany -- 3. Analysis of HSV oncolytic virotherapy in organotypic cultures / Giulia Fulci, Brent Passer -- 4. Use of minicircle plasmids for gene therapy / Peter Mayrhofer, Martin Schleef, Wolfgang Jechlinger -- 5. Transposable elements as plasmid-based vectors for long-term gene transfer into tumors / John R. Ohlfest, Zoltán Ivics, Zsuzsanna Izsvák -- 6. Designing plasmid vectors / Oleg Tolmachov -- 7. Development of bacterial vectors for tumor-targeted gene therapy / Li-Jun Jia and Zi-Chun Hua -- Subsection C Nonviral transfer technologies in cancer gene therapy -- 8. Electroporative gene transfer / Marco Schmeer -- 9. Gene gun delivery systems for cancer vaccine approaches / Kandan Aravindaram and Ning Sun Yang -- 10. Ultrasound-mediated gene transfection / Loreto B. Feril Jr. -- 11. Nonviral jet-injection technology for intratumoral in vivo gene transfer of naked DNA / Wolfgang Walther [and others] -- Subsection D: Experimental studies in cancer gene therapy -- 12. Methods for constructing and evaluating antitumor DNA vaccines / Brian M. Olson and Douglas G. McNeel -- 13. Immunity of lentiviral vector-modified dendritic cells / Shuhong Han and Lung-Ji Chang -- 14. Saporin suicide gene therapy / Natasa Zarovni, Riccardo Vago, and Maria Serena Fabbrini -- 15. Using in vivo biopanning for the development of radiation-guided drug delivery systems / Jerry J. Jaboin, Zhaozhong Han, and Dennis E. Hallahan -- 16. Chemosensitization of Tumor Cells: Inactivation of nuclear factor-kappa B associated with chemosensitivity in melanoma cells after combination treatment with E2F-1 and doxorubicin / Hongying Hao, H. Sam Zhou, and Kelly M. McMasters -- 17. Induction of tumor cell apoptosis by TRAIL gene therapy / Thomas S. Griffith -- 18. Silencing epidermal growth factor receptor by RNA interference in glioma / Chunsheng Kang, Peiyu Pu, and Hao Jiang -- 19. Delivery of phosphorodiamidate morpholino antisense oligomers in cancer cells / Gayathri R. Devi -- 20. Use of RNA aptamers for the modulation of cancer cell signaling / Sunjoo Jeong, Hee Kyu Lee, and Mee Young Kim -- 21. G-rich oligonucleotides for cancer treatment / Paula J. Bates, Enid W. Choi, and Lalitha V. Nayak.
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Section 2. Clinical approaches in cancer gene therapy -- Subsection A. Requirements for clinical gene therapy trials -- 22. Regulatory aspects for translating gene therapy research into the clinic / Carolyn M. Laurencot and Sheryl Ruppel -- 23. Ethics of cancer gene transfer clinical research / Jonathan Kimmelman -- 24. Virus production for clinical gene therapy / Tiago Vicente [and others] -- 25. Production of plasmid DNA as pharmaceutical / Martin Schleef and Markus Blaesen --Subsection B. Clinical protocols in cancer gene therapy -- 26. Gene immunotherapy for non-small cell lung cancer / John J. Nemunaitis -- 27. Gene therapy for antitumor vaccination / Seunghee Kim-Schulze and Howard L. Kaufman -- 28. HSV-tk/IL-2 gene therapy for glioblastoma multiforme / Luisa Barzon [and others] -- 29. Construction and characterization of an oncolytic HSV vector containing a fusogenic glycoprotein and prodrug activation for enhanced local tumor control / Guy R. Simpson and Robert S. Coffin -- 30. Newcastle disease virus: a promising vector for viral therapy, immune therapy, and gene therapy of cancer / Volker Schirrmacher and Philippe Fournier -- 31. Oncolytic viral therapy using reovirus / Chandini Thirukkumaran and Don G. Morris -- 32. Design and testing of novel oncolytic vaccinia strains / Steve H. Thorne -- 33. Tumor-targeted salmonella typhimurium overexpressing cytosine deaminase: a novel, tumor-selective therapy / Ivan King, Martina Itterson, and David Bermudes -- 34. Chemoprotection by transfer of resistance genes / Tulin Budak-Alpdogan and Joseph R. Bertino -- 35. Phase I clinical trial of locoregional administration of the oncolytic adenovirus ONYX-015 in combination with mitomycin-C, doxorubicin, and cisplatin chemotherapy in patients with advanced sarcomas / Mateusz Opyrchal, Ileana Aderca, and Evanthia Galanis.
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| Abstract
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Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data. Gene Therapy of Cancer: Methods and Protocols, Second Edition fully updates the first edition with expert coverage of established and novel protocols involving both experimental and clinical approaches to cancer gene therapy. This state-of-the-art volume contains overviews of new concepts and strategies with chapters on regulatory and ethical issues, developments, problems and possible limitations of design and production of gene therapeutics as well as translational issues. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting edge and authoritative, Gene Therapy of Cancer: Methods and Protocols, Second Edition is an ideal guide for all those who wish to explore the fast-paced and critical study of nonviral, viral, experimental and clinical cancer gene therapy.
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| Subject
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Cancer-- Gene therapy, Laboratory manuals.
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| Subject
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Cancer-- Gene therapy.
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| Subject
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Cancer-- Thérapie génique.
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| Subject
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Neoplasms-- therapy.
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| Subject
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Genetic Therapy-- methods.
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| Dewey Classification
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616.99/4042
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| LC Classification
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RC271.G45G484 2009
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| NLM classification
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QZ 266
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| Added Entry
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Stein, Ulrike.
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Walther, Wolfgang.
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