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" Preclinical drug development / "
edited by Mark C. Rogge, David R. Taft.
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BL
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| Record Number
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1032288
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| Doc. No
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b786658
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| Title & Author
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Preclinical drug development /\ edited by Mark C. Rogge, David R. Taft.
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| Edition Statement
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2nd ed.
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| Publication Statement
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New York, NY :: Informa Healthcare,, 2010.
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| Series Statement
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Drugs and the pharmaceutical sciences ;; 187
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| Page. NO
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1 online resource (viii, 359 pages) :: illustrations (some color)
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| ISBN
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1420084739
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: 9781420084733
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1420084720
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9781420084726
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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The scope of preclinical drug development : an introduction and framework / Mark C. Rogge -- Lead molecule selection : pharmaceutical profiling and toxicity assessments / P.L. Bullock -- Interspecies differences in physiology and pharmacology : extrapolating preclinical data to human populations / M.N. Martinez -- Pharmacokinetics/ADME of small molecules / A.D. Ajavon and David R. Taft -- Pharmacokinetics/ADME of large molecules / R. Braeckman -- Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development / P.L. Bonate and P. Vicini -- Formulation and production strategies for enhancing bioavailability of poorly absorbed drugs / A.B. Watts and R.O. Williams III -- Transporters involved in drug disposition, toxicity, and efficacy / C.Q. Xia and G.T. Miwa -- Toxicity evaluations, ICH guidelines, and current practice / J.L. Larson -- Application of pathology in safety assessment / Robert A. Ettlin and David E. Prentice -- Utilizing the preclinical database to support clinical drug development / H. Lee.
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| Abstract
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Discusses the broad realm of preclinical drug development.
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| Subject
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Drug development.
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Drug development.
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MEDICAL-- Drug Guides.
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MEDICAL-- Nursing-- Pharmacology.
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MEDICAL-- Pharmacology.
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MEDICAL-- Pharmacy.
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Drug Evaluation, Preclinical-- methods.
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Drug Industry-- methods.
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| Dewey Classification
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615/.19
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| LC Classification
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RM301.25.P745 2010eb
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| NLM classification
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QV 771P9227 2010
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W1DR893B v.187 2010
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| Added Entry
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Rogge, Mark C.
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Taft, David R.
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