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" In vitro methods in pharmaceutical research / "
edited by José V. Castell and María José Gómez-Lechón.
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BL
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| Record Number
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1033771
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| Doc. No
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b788141
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| Title & Author
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In vitro methods in pharmaceutical research /\ edited by José V. Castell and María José Gómez-Lechón.
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| Publication Statement
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San Diego :: Academic Press,, ©1997.
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| Page. NO
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1 online resource (ix, 467 pages) :: illustrations
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| ISBN
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0080534600
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: 012163390X
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: 1281466816
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: 9780080534602
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: 9780121633905
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: 9781281466815
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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D.W. Straughan, J.H. Fentem, and M. Balls, Replacement Alternative and Complementary In Vitro Methods in Pharamaceutical Research. -- M.D. Barratt and M. Chamberlain, Integration of QSAR and In Vitro Toxicology. -- F.A. Barile, Continuous Cell Lines as a Model for Drug Toxicity Assessment. -- P. Bach, In Vitro Models for Nephrotoxicity Studies. -- A.E.M. Vickers, Experimental In Vitro Models to Evaluate Hepatotoxicity. -- M.J. Gomez-Lechon, T. Donato, X. Ponsoda, R. Fabra, R. Trullenque, and J.V. Castell, Isolation, Culture and Use of Human Hepatocytes in Drug Research. -- E. McFarlane-Abdulla, and I.C. Campbell, Studies of Nephrotoxicity in Cellular Studies. -- M. Adolphe, S. Thenet-Gauci, and S. Demignot, Chondrocyte Culture: A Target System to Evaluate Pharmaco-Toxicological Effects of Drugs. -- E. Chacon, D. Acosta, and J.J. Lemasters, Primary Cultures of Cardiac Myocytes as In Vitro Models for Pharmacological andToxicological Assessments. -- R. Roguet, Cutaneous Pharmacotoxicology In Vitro. -- H. Spielmann, Ocular Irritation. -- M.A. Miranda, Phototoxicity of Drugs. -- I. de G. Mitchell and R.D. Combes, In Vitro Genotoxicity and Cell Transformation Assessment. -- B. Schmid, R. Bechter, and P. Kucera, The Use of Whole Embryo Cultures in In Vitro Teratogenicity Testing. -- J.V. Castell, M.J. Gomez-Lechon, X. Ponsoda, and R. Bort, In Vitro Investigation of the Molecular Mechanisms of Hepatotoxicity. -- A. Guillouzo, Biotransformation of Drugs by Hepatocytes. -- K. Mace, E.A. Offord, and A.M.A. Pfeifer, Drug Metabolism and Carcinogen Activation Studies with Human Genetically Engineered Cells.
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| Abstract
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In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies. Key Features * Meets the continuing demand for information in this field * Compares In Vitro techniques with other methods * Describes cell-culture methods used to investigate toxicity in cells derived from different organs * Includes contributions by leading experts in the field.
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Drugs-- Research.
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Pharmacy-- Research.
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Drugs-- Research.
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MEDICAL-- Pharmacology.
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Pharmacy-- Research.
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Drug-Related Side Effects and Adverse Reactions.
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Toxicity Tests.
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Farmacie.
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In-vitro-onderzoek.
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Cells, Cultured-- drug effects.
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| Dewey Classification
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615.7
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| LC Classification
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RS122.I52 1997
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| NLM classification
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1996 M-025
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QV 602I348 1997
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| Added Entry
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Castell, José V.
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Gómez-Lechón, María José.
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