| Document Type
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BL
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| Record Number
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1041262
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| Doc. No
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b795632
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| Main Entry
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International Conference on New Strategies for the Treatment of Liver Cirrhosis(2001 :, Tokyo, Japan)
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| Title & Author
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Extracellular matrix and the liver : : approach to gene therapy /\ edited by Isao Okazaki [and others].
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| Publication Statement
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Amsterdam ;Boston :: Academic Press,, ©2003.
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| Page. NO
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1 online resource (xxi, 467 pages) :: illustrations
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| ISBN
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0080531504
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: 012525251X
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: 1281037729
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: 6611037721
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: 9780080531502
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: 9780125252515
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: 9781281037725
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: 9786611037727
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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New Insights into the Extracellular Matrix. -- Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors. -- Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates. -- Functions of Proteoglycan/Glycosaminoglycan in Liver; SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology. -- Cells Responsible for ECM Production in the Liver. Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential. -- Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair. -- Molecular Mechanism of Stellate Cell Activation and ECM Remodeling. -- Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype. Knockout Mice of Matrix Metalloproteinase Genes. Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis.
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| Abstract
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Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology.
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| Subject
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Extracellular matrix.
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| Subject
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Liver-- Cirrhosis-- Gene therapy.
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| Subject
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Liver-- Cirrhosis-- Treatment.
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Extracellular matrix.
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Liver-- Cirrhosis-- Treatment.
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Liver Cirrhosis-- pathology, Congresses.
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Extracellular Matrix-- genetics, Congresses.
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| Subject
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Liver Cirrhosis-- therapy, Congresses.
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| Dewey Classification
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616.362406
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| LC Classification
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RC848.C5E96 2003eb
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| NLM classification
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2003 D-810
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WI 725I602e 2003
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| Added Entry
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Okazaki, Isao.
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