| Document Type
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BL
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| Record Number
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1041943
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| Doc. No
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b796313
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| Main Entry
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Knight, Julian C.
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| Title & Author
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Human genetic diversity : : functional consequences for health and disease /\ Julian C. Knight.
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| Publication Statement
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Oxford ;New York :: Oxford University Press,, 2009.
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| Page. NO
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1 online resource (xix, 480 pages) :: illustrations, maps
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| ISBN
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0191572586
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: 0191711012
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: 9780191572586
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: 9780191711015
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0199227691
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0199227705
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9780199227693
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9780199227709
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Preface; Acknowledgements; 1 Lessons from haemoglobin; 2 Finding genes and specific genetic variants responsible for disease; 3 Cytogenetics and large scale structural genomic variation; 4 Copy number variation in health and susceptibility to disease; 5 Submicroscopic structural variation and genomic disorders; 6 Segmental duplications and indel polymorphisms; 7 Tandem repeats; 8 Mobile DNA elements; 9 SNPs, HapMap, and common disease; 10 Fine scale sequence diversity and signatures of selection; 11 Genetics of gene expression.
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| Abstract
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The secrets of our genetic heritage are finally being unlocked. The massive scientific effort to sequence the human genome is in fact just the beginning of a long journey as the extraordinary genetic diversity that exists between individuals becomes clear. Work in this field promises much: to understand our evolutionary origins, to define us as individuals, to predict our risk of disease and to more effectively understand, treat and prevent illness. Contemporary genetic research isallowing the basis of both rare inherited disorders and common multifactorial diseases like asthma and diabetes to.
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| Subject
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Human evolution.
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Human genetics-- Variation.
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Human molecular genetics.
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HEALTH FITNESS-- Diseases-- Genetic.
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Human evolution.
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Human genetics-- Variation.
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Human molecular genetics.
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MEDICAL-- Genetics.
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| Subject
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Genetic Variation.
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Evolution, Molecular.
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| Dewey Classification
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616/.042
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| LC Classification
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QH431.K556 2009eb
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