| Document Type
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BL
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| Record Number
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1042217
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| Doc. No
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b796587
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| Title & Author
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New antibiotic targets /\ edited by W. Scott Champney.
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| Publication Statement
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Totowa, N.J. :: Humana Press,, ©2008.
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| Series Statement
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Methods in molecular medicine ;; 142
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| Page. NO
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1 online resource (xi, 274 pages) :: illustrations
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| ISBN
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1597452467
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: 9781597452465
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1588299155
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9781588299154
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Biocomputational strategies for microbial drug target identification / K.R. Sakharkar, M.K. Sakharkar and V.T. Chow -- Methods to assay inhibitors of DNA gyrase and topoisomerase iv activities / L.M. Fisher and X.S. Pan -- A method to assay inhibitors of DNA polymerase iiic activity / M.M. Butler and G.E. Wright -- Methods to identify and characterize inhibitors of bacterial RNA polymerase / A.S. Lynch and Q. Du -- Methods to assay inhibitors of trna synthetase activity / D. Beyer, H.P. Kroll and H. Brotz-Oesterhelt -- Three methods to assay inhibitors of ribosomal subunit assembly / W.S. Champney -- Inhibition of chaperone-dependent bacterial ribosome biogenesis / A. Al Refaii and J.H. Alix -- Assays for the identification of inhibitors targeting specific translational steps / L. Brandi, J. Dresios and C.O. Gualerzi -- Spark: A new peptidyl transferase activity assay / A.S. Mankin and N. Polacek -- High-throughput screening of peptide deformylase inhibitors / K.T. Nguyen and D. Pei -- A method to assay penicillin-binding proteins / M.J. Pucci and T.J. Dougherty -- A method to assay inhibitors of lipopolysaccharide synthesis / M. Hernick and C.A. Fierke -- Methods for assessing the structure and function of cationic antimicrobial peptides / M. Pate and J. Blazyk -- Flow cytometry of bacterial membrane potential and permeability / H.M. Shapiro -- Bacterial efflux pump inhibitors / B.J. Kamicker [and others] -- Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase iii (mtfabh) assay: Principles and method / S. Sachdeva and K.A. Reynolds -- Screening for compounds that affect the interaction between bacterial two-component signal transduction response regulator protein and cognate promoter DNA / M.G. Erickson, A.T. Ulijasz and B. Weisblum -- The activity of rrna resistance methyltransferases assessed by maldi mass spectrometry / S. Douthwaite, R.L. Jensen and F. Kirpekar -- Assays for beta-lactamase activity and inhibition / T. Viswanatha [and others] -- Studies of enzymes that cause resistance to aminoglycosides antibiotics / E.H. Serpersu, C. Ozen and E. Wright.
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| Abstract
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A crisis is developing in the treatment of infectious diseases, with microorganisms frequently showing resistance to currently prescribed antibiotics. Fewer and fewer antimicrobial agents are now available to treat these infections. In "New Antibiotic Targets, " W. Scott Champney examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. With detailed methods and protocols for the identification and assay of these targets, "New Antibiotic Targets" provides laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.
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Anti-infective agents-- Testing.
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Drug resistance in microorganisms.
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Drug targeting.
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Anti-infective agents-- Testing.
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Drug resistance in microorganisms.
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Drug targeting.
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Drug Resistance, Microbial.
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Anti-Infective Agents.
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Drug Delivery Systems-- methods.
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| Dewey Classification
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616.9041
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| LC Classification
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QR177.N49 2008
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| NLM classification
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QW 25N5305 2008
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W1ME9616JM v.142 2008
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| Added Entry
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Champney, W. Scott.
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