| Document Type
|
:
|
BL
|
| Record Number
|
:
|
1042623
|
| Doc. No
|
:
|
b796993
|
| Title & Author
|
:
|
Death receptors in cancer therapy /\ edited by Wafik S. El-Deiry.
|
| Publication Statement
|
:
|
Totowa, N.J. :: Humana Press,, ©2005.
|
| Series Statement
|
:
|
Cancer drug discovery and development
|
| Page. NO
|
:
|
1 online resource (xi, 374 pages) :: illustrations
|
| ISBN
|
:
|
1588291723
|
|
|
:
|
: 159259851X
|
|
|
:
|
: 9781588291721
|
|
|
:
|
: 9781592598519
|
| Bibliographies/Indexes
|
:
|
Includes bibliographical references and index.
|
| Contents
|
:
|
Mammalian cell death pathways: intrinsic and extrinsic -- Resistance to apoptosis in cancer therapy -- Structures of TNF receptors and their interactions with ligands -- Death receptor signaling in embryonic ectodermal development -- Adaptor proteins in death receptor signalin -- Caspase activation by the extrinsic pathway -- Death signaling and therapeutic applications of TRAIL -- Death receptor mutations -- Regulation of death receptors -- Regulation of trail receptor expression in human melanoma -- Regulation of death receptors by synthetic retinoids -- Role of p53 in regulation of death receptors -- Proapoptotic gene silencing via methylation in human tumors -- Regulation of death receptor-induced apoptosis by NF-kB and interferon signaling pathways: implications for cancer therapy -- TRAIL in cancer therapy -- Expression and regulation of death receptors in multiple myeloma and prostate carcinoma -- Regulation of TRAIL-induced apoptosis by transcriptional factors -- Sensitizing tumor cells by targeting death receptor signaling inhibitors -- Ceramide, ceramidase, and FasL gene therapy in prostate cancer -- Gene therapy targeting receptor-mediated cell death the cancer -- Combination of chemotherapy and death ligands in cancer therapy.
|
| Abstract
|
:
|
This is an in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. The topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death.
|
| Subject
|
:
|
Apoptosis.
|
| Subject
|
:
|
Cancer-- Molecular aspects.
|
| Subject
|
:
|
Cell receptors.
|
| Subject
|
:
|
Cellular signal transduction.
|
| Subject
|
:
|
Apoptose.
|
| Subject
|
:
|
Cancer-- Aspect moléculaire.
|
| Subject
|
:
|
Récepteurs cellulaires.
|
| Subject
|
:
|
Transduction du signal cellulaire.
|
| Subject
|
:
|
Apoptosis.
|
| Subject
|
:
|
Cancer-- Molecular aspects.
|
| Subject
|
:
|
Cell receptors.
|
| Subject
|
:
|
Cellular signal transduction.
|
| Subject
|
:
|
SCIENCE-- Life Sciences-- Anatomy Physiology.
|
| Subject
|
:
|
Apoptosis.
|
| Subject
|
:
|
Cancer-- Molecular aspects.
|
| Subject
|
:
|
Cell Death-- immunology.
|
| Subject
|
:
|
Cell receptors.
|
| Subject
|
:
|
Cellular signal transduction.
|
| Subject
|
:
|
Gene Therapy-- methods.
|
| Subject
|
:
|
Neoplasms-- immunology.
|
| Subject
|
:
|
Neoplasms-- therapy.
|
| Subject
|
:
|
Receptors, Tumor Necrosis Factor.
|
| Subject
|
:
|
Neoplasms-- immunology.
|
| Subject
|
:
|
Neoplasms-- therapy.
|
| Subject
|
:
|
Celdood.
|
| Subject
|
:
|
Genen.
|
| Subject
|
:
|
Kanker.
|
| Subject
|
:
|
Signalen.
|
| Subject
|
:
|
Cell Death-- immunology.
|
| Subject
|
:
|
Genetic Therapy-- methods.
|
| Subject
|
:
|
Receptors, Tumor Necrosis Factor.
|
| Dewey Classification
|
:
|
571.9/36
|
| LC Classification
|
:
|
QH671.D43 2005
|
| NLM classification
|
:
|
2005 C-352
|
|
|
:
|
QZ 266D285 2005
|
|
|
:
|
44.81bcl
|
|
|
:
|
R730. 5clc
|
| Added Entry
|
:
|
El-Deiry, Wafik S.
|