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" Drug-drug interactions in pharmaceutical development / "
edited by Albert P. Li.
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BL
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| Record Number
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1043242
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b797612
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| Title & Author
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Drug-drug interactions in pharmaceutical development /\ edited by Albert P. Li.
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| Publication Statement
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Hoboken, N.J. :: Wiley-interscience,, ©2008.
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| Series Statement
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Wiley series in drug discovery and development
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| Page. NO
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1 online resource (xiv, 244 pages, [1] pages) :: illustrations (some color)
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| ISBN
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0470187913
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: 0470187921
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: 1282022067
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: 661202206X
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: 9780470187913
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: 9780470187920
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: 9781282022065
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: 9786612022067
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0471794414
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9780471794417
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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In vitro evaluation of metabolic drug-drug interactions: concepts and practice / Albert P. Li -- In vitro approaches to anticipating clinical drug interactions / Laurie P. Volak, David J. Greenblatt, Lisa L. von Moltke -- Inhibition of drug metabolizing enzymes and drug-drug interactions in drug discovery and development / R. Scott Obach -- Mechanism-based CYP inhibition: enzyme kinetics, assays, and prediction of human drug-drug interactions / Magang Shou -- Genomic approaches to drug-drug interactions / Yi Yang, Jeffrey F. Waring -- Transporters and drug interactions / Yoshihisa Shitara, Toshiharu Horie, and Yuichi Sugiyama -- Transporter-mediated drug interactions: molecular mechanisms and clinical implications / Jiunn H. Lin -- Recent case studies of clinically significant drug-drug interactions and the limits of in vitro prediction methodology / R.H. Levy, I. Ragueneau-Majlessi, C. Collins -- US regulatory perspective: drug-drug interactions / John Strong and Shiew-Mei Huang -- Herbal drug interactions: a Canadian perspective / Brian C. Foster.
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| Abstract
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Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.
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| Subject
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Drug development.
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Drug interactions.
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Interactions médicamenteuses.
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Arzneimittelentwicklung
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Arzneimittelwechselwirkung
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Drug development.
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Drug interactions.
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MEDICAL-- Pharmacology.
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Drug Interactions.
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Chemistry, Pharmaceutical.
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| Dewey Classification
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615/.7045
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| LC Classification
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RM302.D755 2008eb
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| NLM classification
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2007 M-292
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QV 38D7916 2008
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| Added Entry
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Li, A. P.
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