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" Apoptosis in health and disease : "
edited by Martin Holcik [and others].
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BL
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| Record Number
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1046747
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| Doc. No
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b801117
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| Title & Author
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Apoptosis in health and disease : : clinical and therapeutic aspects /\ edited by Martin Holcik [and others].
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| Publication Statement
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London ;New York :: Cambridge University Press,, 2005.
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| Page. NO
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ix, 249 pages :: illustrations ;; 26 cm
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| ISBN
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0521529565
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: 9780521529563
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9780521529565
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Apoptosis in health, disease and therapy: overview and methodology -- Developmental apoptosis in health and disease -- Apoptosis and cancer -- Neuronal cell death in human neurodegenerative diseases and their animal/cell models -- Apoptosis in the cardiovascular system: incidence, regulation, and therapeutic options -- Cytotoxic lymphocytes, apoptosis, and autoimmunity -- Pro- and anti-apoptotic strategies of viruses.
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| Abstract
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The process of programmed cell death or apoptosis has, in the past decade, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states.
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| Subject
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Apoptosis.
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Pathology, Cellular.
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Apoptosis.
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Pathology, Cellular.
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Apoptosis-- physiology.
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Celdood.
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Apoptosis-- drug effects.
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| Dewey Classification
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571.9/36
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| LC Classification
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QH671.A6576 2005
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| NLM classification
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2005 D-291
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QH 671A643793 2005
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44.47bcl
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44.47.bcl
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| Added Entry
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Holcik, Martin,1967-
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