Studies of Stroke-Associated Risk Factor Genes in Apical Periodontitis

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" Studies of Stroke-Associated Risk Factor Genes in Apical Periodontitis "
Rizzo, Gabriella Letra, Ariadne

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	1104079
Doc. No	:	TLpq2164266972
Main Entry	:	Letra, Ariadne
	:	Rizzo, Gabriella
Title & Author	:	Studies of Stroke-Associated Risk Factor Genes in Apical Periodontitis\ Rizzo, GabriellaLetra, Ariadne
College	:	The University of Texas School of Dentistry at Houston
Date	:	2019
student score	:	2019
Degree	:	M.Sc.D.
Page No	:	57
Abstract	:	Introduction: Apical periodontitis (AP) and cardiovascular disease (CVD) share endothelial inflammatory dysfunction as part of their etiology and multiple studies have suggested that an association exists between these conditions. Cerebrovascular disease (stroke) results from some of the same events as CVD, with hypertension being the most robust risk factor for stroke. We have previously reported on the association between hypertension and AP using epidemiologic and genetic approaches. In this study, we investigated the association between AP and stroke in a case-control population with and without AP. Methods: Clinical data and DNA samples from patients with (n=229) and without AP (n=213) recruited at the University of Texas School of Dentistry at Houston Endodontic Clinic were used for this study. Six single nucleotide polymorphism (SNPs) in stroke-associated risk factor genes were selected for genotyping our study population using Taqman chemistry in real time PCR. Data analysis was performed using chi-square and Fisher Exact tests as implemented in PLINK Software. P ≤ 0.05 indicated statistical difference between groups. Results: No significant genetic associations were found between the investigated polymorphisms in stroke risk factor genes and AP (P > 0.05). Conclusion: Within the limitations of this study, no association was found between stroke-related genes and AP. Studies with larger sample sizes and/or different genes should be performed to elucidate if potential correlations between these two conditions indeed exist.
Subject	:	Dentistry
	:	Epidemiology
	:	Physiology
	:	Public health