Demographics and Quality of Life Effects of Normobaric Oxygen on Cohort of Patients with Retinal Vei...

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" Demographics and Quality of Life Effects of Normobaric Oxygen on Cohort of Patients with Retinal Vein Occlusions "
Minturn, Robert J. Arroyo, Jorge

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	1104813
Doc. No	:	TLpq2270040750
Main Entry	:	Arroyo, Jorge
	:	Minturn, Robert J.
Title & Author	:	Demographics and Quality of Life Effects of Normobaric Oxygen on Cohort of Patients with Retinal Vein Occlusions\ Minturn, Robert J.Arroyo, Jorge
College	:	Boston University
Date	:	2019
student score	:	2019
Degree	:	M.S.
Page No	:	56
Abstract	:	Purpose: This study examined the effects of normobaric oxygen in patients diagnosed with either a Central Retinal Vein Occlusion (CRVO) or Branched Retinal Vein Occlusion (BRVO) who had previously undergone treatment via Anti-VEGF or PRP treatment. The investigation looked into the changes in Macular Thickness (MT) and Visual Acuity (VA). Methods: This pilot study analyzed patient data from Beth Israel Deaconess Medical Center (Boston, MA) that had been diagnosed with Retinal Vein Occlusions. The patients were brought in and given 3 hours of normobaric oxygen via an oxygen concentrator with imaging and vision checked both before and after the therapy. Results: Eighty-eight percent of our patients in this pilot study saw a decrease in macular thickness after 3-hour oxygen therapy. The mean change in Maximal Macular Thickness was a decrease of 7.1% which was statistically significant when compared to healthy eyes (p<0.001). Additionally, 44% of patients saw an increase in visual acuity, the primary measure of vision. Visual acuity showed a statistically significant change when compared to changes in healthy eyes (p=0.015). No statistical significance was found in the testing of contrast sensitivity nor intraocular pressure. Conclusion: Our study showed improvement in central macular thickness and quality of life for individuals using noninvasive normobaric hyperoxia as a treatment for retinal vein occlusions. However, further research is needed to improve the impact of the study and a full randomized control trial should be implemented to further understand the potential impacts of a noninvasive normobaric hyperoxia treatment as a means to alleviate symptoms in retinal vein occlusions. In addition, in the future oxygen supplementation in conjunction with periodic injections of Anti-VEGF could be investigated as a treatment regimen with potential benefits beyond individual therapy.
Subject	:	Biochemistry
	:	Medicine
	:	Ophthalmology
	:	Physiology
	:	Public health