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" Characterization and Evolution of Intracellular Survival in Bordetella "
Rivera, Israel
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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1107363
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| Doc. No
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TLpq2443598795
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| Main Entry
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Rivera, Israel
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| Title & Author
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Characterization and Evolution of Intracellular Survival in Bordetella\ Rivera, Israel
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| College
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University of Georgia
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| Date
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2020
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| student score
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2020
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| Degree
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Ph.D.
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| Page No
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170
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| Abstract
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The classical bordetellae possess several partially characterized virulence mechanisms that are studied in the context of a complete extracellular life cycle in their mammalian host. Yet, classical bordetellae have repeatedly been reported within dendritic cells and alveolar macrophages in clinical samples, and in vitro experiments convincingly demonstrate that the bacteria can survive intracellularly within mammalian phagocytic cells, an ability that appears to have descended from ancestral progenitor species that lived in the environment and acquired the mechanisms to resist unicellular phagocytic predator. Many pathogens, including Mycobacterium tuberculosis, Salmonella enterica, Francisella tularensis, and Legionella pneumophila are known to parasitize and multiply inside eukaryotic host cells. This strategy provides protection, nutrients, and the ability to disseminate systemically. While some work has been dedicated at characterizing B. pertussis intracellular survival phenotype, there is very little understanding of how this strategy has evolved within the genus Bordetella and contributes to bacterial pathogenicity, evasion of host immunity and systemic dissemination. Here, we explore the mechanisms that control the changes accompanying intracellular survival and how these have been acquired and conserved throughout the divergent evolutionary histories of Bordetella species.
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Bioinformatics
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Microbiology
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Molecular biology
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