Virus and chemical-induced immunosuppression in nonhuman primates

مرکز و کتابخانه مطالعات اسلامی به زبان های اروپایی

منو

" Virus and chemical-induced immunosuppression in nonhuman primates "
M. A. Javadian J. L. Botsford

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	1112347
Doc. No	:	TLpq303918510
Main Entry	:	J. L. Botsford
	:	M. A. Javadian
Title & Author	:	Virus and chemical-induced immunosuppression in nonhuman primates\ M. A. JavadianJ. L. Botsford
College	:	New Mexico State University
Date	:	1991
student score	:	1991
Degree	:	Ph.D.
Page No	:	118
Abstract	:	A successful cellular immune response includes macrophages, neutrophils, natural killer cells, and lymphocytes. Modulation or interference with any of these components leads to suppression of the host immune response. The effects of hepatitis B (HBV), hepatitis Non-A, Non-B (NANB) human immunodeficiency virus (HIV), and the chemical pesticide, heptachlor, on the initial aspects of immune response of exposed chimpanzees were investigated. The effects of HBV, NANB, and HIV on the function of polymorphonuclear leukocytes (PMN) were studied by employing a chemiluminescence (CL) assay. The present data have shown that all three viruses impair the generation of the respiratory burst by PMNs. The effect of viruses and heptachlor on the blastogenesis of chimpanzee lymphocytes was investigated by mitogenic stimulation and mixed lymphocyte reactions (MLR). Exposure of chimpanzee lymphocytes to heptachlor produced a significant decrease on the proliferative response of mitogens and mitomycin-treated allogenic cells. The natural killer (NK) cell cytotoxicity of HIV-infected chimpanzees was measured by Cr-release assay. The data from this study indicate that NK cytotoxic function was severely compromised in HIV-infected chimpanzees. Of potential relevance was the observation that cytolytic activity of depressed NK cells was restored after in vitro treatment with interleukin-2. Evidence from this study indicates that effects of heptachlor on the initial aspects of immune response in non-human primates are very much like that caused by HIV and hepatitis viruses.
Subject	:	Biological sciences
	:	Health and environmental sciences
	:	Immunology
	:	Immunology
	:	Microbiology
	:	Toxicology