Chemical analysis of some penicillin and cephalosporin drugs

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" Chemical analysis of some penicillin and cephalosporin drugs "
S. S. Yassin

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	1112725
Doc. No	:	TLpq230755001
Main Entry	:	S. S. Yassin
Title & Author	:	Chemical analysis of some penicillin and cephalosporin drugs\ S. S. Yassin
College	:	King Fahd University of Petroleum and Minerals (Saudi Arabia)
Date	:	1991
student score	:	1991
Degree	:	M.S.
Page No	:	179
Abstract	:	This thesis describes work on the polarographic analysis of pencillin and cephalosporin antibiotics. Methods for the quantitative analysis of Ampicillin, Amoxycillin and Cephalexin were developed. These methods are based on the formation of Ni(II) or Co(II) complexes of the antibiotics or on degradation products namely, 2,5-diketopiperazine derivatives. The optimum conditions of buffering, support electrolyte, pH, temperature and the effect of time were studied for the Ni(II) complexes of Ampicillin and Amoxycillin. Under these optimum conditions, linear calibration ranges were usd5.00\times 10\sp{-7}usd to usd1.00\times 10\sp{-5}Musd and usd4.00\times 10\sp{-7}usd to usd2.00\times 10\sp{-5}Musd for Ampicillin and Amoxycillin respectively. Reversibility tests suggest that the electrode reactions are probably reversible and they are one electron transfer processes. The Co(II) complex of Cephalexin was compared with that of Ni(II) for the analysis and found to be inferior. A satisfactory method based on the formation of the 2,5-diketopiperazine derivatives of Amoxycillin was developed. The methods devised were tested on pharmaceutical products (capsules) and the results compared with pharmacopoeia methods. Good agreement was obtained.
Subject	:	Analytical chemistry
	:	Analytical chemistry
	:	Pharmacology
	:	Pure sciences