Voltammetric assays and behavior of norfloxacin and nalidixic acid antibacterial drugs

مرکز و کتابخانه مطالعات اسلامی به زبان های اروپایی

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" Voltammetric assays and behavior of norfloxacin and nalidixic acid antibacterial drugs "
A. Lounici

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	1113218
Doc. No	:	TLpq230940034
Main Entry	:	A. Lounici
Title & Author	:	Voltammetric assays and behavior of norfloxacin and nalidixic acid antibacterial drugs\ A. Lounici
College	:	King Fahd University of Petroleum and Minerals (Saudi Arabia)
Date	:	1993
student score	:	1993
Degree	:	M.S.
Page No	:	216
Abstract	:	This thesis describes the work done on the voltammetric assays, physicochemical behavior, and mechanistic studies of norfloxacin and nalidixic and antibacterial drugs at the dropping mercury electrode (DME) and at the hanging mercury drop electrode (HMDE). Easy, precise, accurate and fast analytical procedures have been developed for the quantitative determination of norfloxacin and nalidixic acid in formulated tablets using differential pulse polarography (DPP), linear scan voltammetry (LSV) and adsorptive striping voltammetry (AdSV). Good working ranges and recoveries with small standard deviations were obtained in the determination of both antibacterials using DPP and LSV techniques with a detection limit of 1 ppm (1 mg/l). Determination of ultra-trace of norfloxacin was possible using the AdSV with a detection limit of 0.31 ppt (0.31 ng/l). The voltammetric behavior and mechanistic study of norfloxacin and nalidixic acid were investigated. Norfloxacin was found to be reduced in one electron step in strongly acidic and in alkaline solution. However, it is reduced in 2 one electron steps in slightly acidic to slightly alkaline solutions (pH 5.5-8.0). The two main reduction waves were found to be irreversible and diffusion controlled with scan rates >20 mV/sec. However, the other smaller waves showed different degree of reversibility depending on the scan rate and were found to be adsorption controlled. Nalidixic acid is found to be reduced in 2 one electron steps in strongly acidic medium and in slightly acidic to slightly alkaline solutions. However, it is reduced in one electron only in alkaline solutions. Its reduction processes were found to be completely irreversible and diffusion controlled.
Subject	:	Chemistry
	:	Pure sciences