Chemometric optimization and kinetic developments in flow injection analysis

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منو

" Chemometric optimization and kinetic developments in flow injection analysis "
F. E. O. Suliman

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	1113435
Doc. No	:	TLpq304334886
Main Entry	:	F. E. O. Suliman
Title & Author	:	Chemometric optimization and kinetic developments in flow injection analysis\ F. E. O. Suliman
College	:	King Fahd University of Petroleum and Minerals (Saudi Arabia)
Date	:	1996
student score	:	1996
Degree	:	Ph.D.
Page No	:	235
Abstract	:	Chemometric optimization methodologies have been utilized for the development of quantitative methods of analysis of some drugs using flow injection (FI) techniques. Super modified simplex procedures together with statistical design techniques have been used for optimization and modeling of response surface. The sequential optimization has validated the flow injection methods proposed with excellent reproducibility, high sensitivity, and a wide dynamic range. A sampling frequency of not less than 120 h was obtained for all methods developed. Sequential injection (SI) technique has been successfully applied for the determination of reaction stoichiometry and formation constant. The 1:1 and 1:2 metal:drug mole ratio have been obtained for the complexation of some phenothiazines with palladium(II) in hydrochloric acid media and for the complexation of some flouroquinolones with iron(III) in sulfuric acid media respectively. For the first time, sequential injection technique has been employed for full kinetics investigation resulting in proposing reasonable mechanism of reactions and adopting kinetic methods of analysis. The complexation reaction of bromazepam with iron(II) was studied in hydrochloric acid media. The orders of the reaction with respect to each reactant were determined and a consistent reaction rate law was offered.
Subject	:	Analytical chemistry
	:	Analytical chemistry
	:	bromazepam
	:	Pharmacology
	:	Pure sciences