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" Polymer-Based Nanostructures for Encapsulation, Conjugation, and Therapeutic Delivery "
Jafari, Amin
Cheng, Chong
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Latin Dissertation
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English
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| Record Number
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1113765
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| Doc. No
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TLpq2386952348
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| Main Entry
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Cheng, Chong
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Jafari, Amin
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| Title & Author
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Polymer-Based Nanostructures for Encapsulation, Conjugation, and Therapeutic Delivery\ Jafari, AminCheng, Chong
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| College
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State University of New York at Buffalo
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| Date
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2019
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2019
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| Degree
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Ph.D.
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| Page No
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184
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| Abstract
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Effective delivery of therapeutic agents, such as free drug molecules and genes, to specific biological sites presents a significant challenge for biomedical researchers. Several biological barriers are hindering the delivery of free therapeutic materials directly to the diseased tissue, such as degradation by serum protein absorption, macrophage internalization, sequestration in the reticuloendothelial system, clearance by the kidney, etc. Over the past decades, nanocarriers have emerged as promising biomaterials that may overcome biological barriers, protect the therapeutic cargo, and effectively deliver them to the diseased tissue. Polymer-based nanocarriers have drawn tremendous interest because of their significant potential to improve therapeutic biocompatibility, solubility, bioavailability, controlled release, and also minimizing therapeutic toxicity, and nonspecific interactions. With a thoughtful structural design, they can exhibit provide biomedical-relevant stimuli-responsive behavior via variables such as pH, light, and temperatures. The formulation of novel polymer-based nanocarriers for therapeutic delivery has been the focus of many researchers over the past decades. Aligned with such a research direction, this dissertation research includes two major projects: 1) nanocapsules preparation by layer-by-layer (LBL) self-assembly, and 2) synthesis and development of multiple polycaprolactone (PCL)-based nanocarriers for drug and gene delivery applications.
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Biodegradable polymer
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Drug and gene delivery
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Functional biomaterial
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Nanocapsule
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Nanoparticle
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Polymer chemistry
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