Understanding the Interplay Between Viral and Host Dynamics

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" Understanding the Interplay Between Viral and Host Dynamics "
Vera Cruz, Diana Koelle, Katharina

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	1114544
Doc. No	:	TLpq2408869575
Main Entry	:	Koelle, Katharina
	:	Vera Cruz, Diana
Title & Author	:	Understanding the Interplay Between Viral and Host Dynamics\ Vera Cruz, DianaKoelle, Katharina
College	:	Duke University
Date	:	2020
student score	:	2020
Degree	:	Ph.D.
Page No	:	151
Abstract	:	The evolution of antigenically variable viruses cannot be understood without studying the interaction between viruses and the host immune system. Viral evolution is driven by their fast acquisition of genetic variation as well as by the strong selection imposed by the host immune response. Moreover, understanding viral evolution dynamics and its interplay on the host immune response can provide essential information for vaccine development. In this dissertation, I use an integrative approach to study various aspects of this interplay in two viral systems: influenza A (IAV) and cytomegalovirus (CMV), both ubiquitous in humans and significant public health threats.
Subject	:	Antigenic imprinting
	:	Biology
	:	Cytomegalovirus
	:	Influenza
	:	Vaccination
	:	Viral evolution