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Document Type:Latin Dissertation
Language of Document:English
Record Number:52539
Doc. No:TL22493
Call number:‭3306239‬
Main Entry:Purnima Madhivanan
Title & Author:Bacterial vaginosis and the risk of Herpes simplex virus type-2 infectionPurnima Madhivanan
College:University of California, Berkeley
Date:2007
Degree:Ph.D.
student score:2007
Page No:127
Abstract:Sexually transmitted infections are among the most common illnesses in the world. In women of childbearing age, sexually transmitted infections (excluding HIV) are second only to maternal mortality as causes of disease, death and years of healthy life lost. Sexually transmitted infections can cause infertility, ectopic pregnancy, stillbirths, and cervical and liver cancer, and increase the likelihood of HIV transmission. Controlling sexually transmitted infections not only reduces mortality and morbidity, it can also be an important strategy for preventing the spread of HIV. Herpes simplex virus type-2 infection (HSV-2) is almost always sexually transmitted and is frequently unrecognized. Asymptomatic HSV-2 infection may be important in facilitating the transmission of HIV, and HSV-2 seropositivity has been found to be a useful marker of high-risk sexual behavior. This dissertation characterized risk factors for HSV-2 among young reproductive age women from low-income rural and peri-urban neighborhoods of Mysore, India and described the correlates of bacterial vaginosis and T. vaginalis infections. Cross-sectional analyses of the baseline findings showed a high burden of reproductive tract infections. Few infected participants had been previously diagnosed or treated for these infections. The prevalence of trichomoniasis was relatively high in this community sample of young reproductive aged women. Symptoms alone were insufficient for a reliable diagnosis of trichomoniasis, while the majority of clinical findings and laboratory tests had good specificity. The syndromic approach to diagnosing trichomoniasis is likely to cause substantial over-treatment of uninfected women and under-diagnosis of asymptomatic infected women. Several risk factors for HSV-2 infections were identified in this population. Years of sexual activity, lower education, not having children, having an unskilled laborer as a sex partner and trichomoniasis were associated with HSV-2 infection. Being Muslim was protective against HSV-2 infection. Public health interventions such as early screening, education, condom promotion, and aggressive treatment of reproductive tract infections such as trichomoniasis offer the best hope for reducing HSV-2 transmission in India.
Subject:Health and environmental sciences; Cohort study; Herpes simplex virus; India; Reproductive tract infections; Sexually transmitted infections; Women; Public health; Epidemiology; Bacteria; Risk factors; Herpes viruses; 0573:Public health; 0766:Epidemiology
Added Entry:A. L. Reingold
Added Entry:University of California, Berkeley