Effect of conjugated linoleic acid on hepatic triglyceride and apolipoprotein B100 metabolism: In vi...

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" Effect of conjugated linoleic acid on hepatic triglyceride and apolipoprotein B100 metabolism: In vivo and in vitro studies "
Patricia L. Mitchell

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	53020
Doc. No	:	TL22974
Call number	:	‭MR16643‬
Main Entry	:	Patricia L. Mitchell
Title & Author	:	Effect of conjugated linoleic acid on hepatic triglyceride and apolipoprotein B100 metabolism: In vivo and in vitro studies\ Patricia L. Mitchell
College	:	Dalhousie University (Canada)
Date	:	2006
Degree	:	M.Sc.
student score	:	2006
Page No	:	89
Abstract	:	Conjugated linoleic acid, a group of positional and geometric isomers of linoleic acid (C18:2 c-9, c-12), have been reported to provide protection against atherosclerosis. Supplementation of a high fat, high cholesterol diet with 1% (w/w) c-9, t-11 CLA or t-10, c-12 CLA did not significantly affect plasma lipid or lipoprotein levels in the Syrian Golden Hamster. However, a reduction in early aortic atherosclerotic lesions was observed for both the c-9, t-11 CLA (38 ± 8%) and the t-10, c-12 CLA groups (28 ± 7%) compared to LA (60 ± 11%). Assembly and secretion of hepatic very low density lipoprotein was studied in McA-RH7777 hepatoma cells. Triglyceride secretion from these cells was decreased with CLA supplementation. However, CLA supplementation stimulated apoB100 synthesis and enhanced its secretion and stability under some conditions. These observations suggest that CLA may affect the assembly and composition of hepatic VLDL. Further studies will be required to fully understand the effect of CLA on VLDL metabolism and atherogenesis.
Subject	:	Pure sciences; Biological sciences; Biochemistry; Molecular biology; 0487:Biochemistry; 0307:Molecular biology
Added Entry	:	Dalhousie University (Canada)