Community intervention to assess the effects of orange -flesh sweet potatoes and vitamin A supplemen...

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" Community intervention to assess the effects of orange -flesh sweet potatoes and vitamin A supplements on mineral absorption from rice -based meals and intestinal mucosal permeability in vitamin A -depleted Bangladeshi women "
Ana Beatriz Perez Exposito

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	53766
Doc. No	:	TL23720
Call number	:	‭3401500‬
Main Entry	:	Ana Beatriz Perez Exposito
Title & Author	:	Community intervention to assess the effects of orange -flesh sweet potatoes and vitamin A supplements on mineral absorption from rice -based meals and intestinal mucosal permeability in vitamin A -depleted Bangladeshi women\ Ana Beatriz Perez Exposito
College	:	University of California, Davis
Date	:	2009
Degree	:	Ph.D.
student score	:	2009
Page No	:	113
Abstract	:	Several studies have found positive effects of vitamin A supplementation on intestinal permeability in infants but little information is available about the etiology of altered intestinal permeability in adults. It is also uncertain whether consumption of foods with high beta-carotene content would have effects on intestinal function as it has been shown with the use of vitamin A supplements in children. Further, zinc and iron deficiencies have been associated with alterations of the intestinal mucosa. Due to the importance of the intestinal mucosa for the selective permeability to essential nutrients, it is possible that alterations in intestinal permeability might affect mineral absorption. The effect that interventions including vitamin A supplements or crops with high beta-carotene content might have on zinc absorption in humans remains unknown. The investigation herein presented was nested within a community controlled feeding trial designed to assess the efficacy of orange-fleshed sweet potatoes (OFSP) to improve the vitamin A status of vitamin A-depleted Bangladeshi women. We recruited participants from this intervention to assess the effect of daily consumption of OFSP with high-beta carotene content or vitamin A supplements on intestinal function, to examine the relationship between intestinal permeability and zinc and iron absorption, and to study the independent effect of vitamin A and beta-carotene intake on zinc absorption in this population of vitamin A-depleted women. The results of this investigation show that daily intake of OFSP or vitamin A supplementation has no effect on intestinal permeability in vitamin A-depleted women. We also found that zinc absorption from a traditional Bangladeshi test meal is increased in women with low vitamin A stores and altered intestinal permeability without any effect of this condition on iron absorption. Our results indicate that the addition of vitamin A to rice-based meals reduces zinc absorption while consumption of OFSP with high beta-carotene content does not have an inhibitory effect. Further, increased intake of OFSP or vitamin A supplementation for 60 days does not affect zinc absorption in vitamin A-depleted Bangladeshi women. Micronutrient supplementation and food fortification have proven to be among the most cost-effective interventions to combat malnutrition, and recently, the use of conventional breeding techniques and biotechnology to improve β-carotene content of certain crops has been implemented as a sustainable and promising approach to improve micronutrient status in lower income countries. The extent to which alterations in intestinal permeability will differentially affect the absorption of these micronutrients or to which these interventions could modify the mucosal integrity not only will determine the impact of nutrition interventions but also its safety. All these factors need to be considered when distributing supplements to millions of children and women living in unsanitary conditions where the prevalence of increased intestinal permeability might be high. Interactions between nutrients as the one we showed exists between vitamin A and zinc absorption will also determine the success of nutrition interventions to improve nutritional status and well-being of underprivileged populations.
Subject	:	Health and environmental sciences; Bangladesh; Intestinal permeability; Iron aborption; Sweet potatoes; Vitamin A; Women; Zinc absorption; Environmental Health; Public health; 0470:Environmental Health; 0573:Public health
Added Entry	:	University of California, Davis