Adolescent anabolic steroid exposure: Effects on social behaviors and neural plasticity

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" Adolescent anabolic steroid exposure: Effects on social behaviors and neural plasticity "
Kaliris Y. Salas-Ramirez C. Sisk

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	54339
Doc. No	:	TL24293
Call number	:	‭3298109‬
Main Entry	:	Kaliris Y. Salas-Ramirez
Title & Author	:	Adolescent anabolic steroid exposure: Effects on social behaviors and neural plasticity\ Kaliris Y. Salas-Ramirez
College	:	Michigan State University
Date	:	2007
Degree	:	Ph.D.
student score	:	2007
Page No	:	142
Abstract	:	Anabolic-androgenic steroids (AAS) are synthetic derivatives of testosterone used by over half a million adolescents in the US for their tissue-building potency and performance enhancing effects. Recent studies show AAS use is increasing among teenagers. AAS have behavioral effects such as heightened aggression and changes in sexual libido in humans. The maturation of adult behavior during adolescence involves complex interactions among hormones, experience, and the developing brain. Our research using Syrian hamsters demonstrates that the absence of gonadal hormones during adolescence irreversibly impairs male reproductive and social communication behaviors in adulthood, indicating that adolescence is a particularly sensitive period for steroid-dependent remodeling of neural circuits underlying complex social behaviors. The overall goal of my work was to determine how AAS interact with the adolescent brain to influence social behaviors during adolescence and in adulthood. Results from my studies show that a cocktail of AAS containing testosterone cypionate, nandrolone decanoate, and boldenone undecylenate increase aggressive and reproductive behaviors in male Syrian hamsters treated for two weeks and tested during adolescence. Nevertheless, the same cocktail has different effects on adult males treated for the same length of time. Both adolescent and adult males suffered from long term effects due to AAS exposure, but only for particular aspects of sexual and agonistic behaviors. Finally, adolescent AAS exposure affects amygdaloid neural plasticity. These data indicate that the adolescent brain responds differently to exogenous hormones than the adult brain, suggesting that the still developing adolescent brain is vulnerable to perturbations in steroid milieu.
Subject	:	Biological sciences; Adolescents; Aggression; Amygdala; Anabolic steroids; Sexual behavior; Social behavior; Neurosciences; 0317:Neurosciences
Added Entry	:	C. Sisk
Added Entry	:	Michigan State University