The physics of chromatin silencing: Bi-stability and front propagation

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منو

" The physics of chromatin silencing: Bi-stability and front propagation "
Mohammad Sedighi A. Sengupta

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	54528
Doc. No	:	TL24482
Call number	:	‭3319449‬
Main Entry	:	Mohammad Sedighi
Title & Author	:	The physics of chromatin silencing: Bi-stability and front propagation\ Mohammad Sedighi
College	:	Rutgers The State University of New Jersey - New Brunswick
Date	:	2007
Degree	:	Ph.D.
student score	:	2007
Page No	:	86
Abstract	:	A mean-field dynamical model of chromatin silencing in budding yeast is provided and the conditions giving rise to two states: one silenced and another un-silenced, is studied. Based on these conditions, the space of control parameters is divided into two distinct regions of mono-stable and bi-stable solutions (the bifurcation diagram). Then, considering both the discrete and continuous versions of the model, the formation of a stable boundary between the silenced and un-silenced areas on DNA is investigated. As a result, a richer phase diagram is provided. The dynamics of the boundary is also studied under different conditions. Consequently, assuming negative feedback due to possible depletion of silencing proteins, the model explains a paradoxical epigenetic behavior of yeast that happens under some mutation. A stochastic treatment of the model is also considered to verify the results of the mean-field approximation and also to understand the role of intrinsic noise at single cell level. This model could be used as a general guide to discuss chromatin silencing in many organisms.
Subject	:	Pure sciences; Biological sciences; Chromatin; Silencing; Bistability; Front propagation; Systems biology; Chromatin silencing; Physics; Biophysics; 0786:Biophysics; 0605:Physics
Added Entry	:	A. Sengupta
Added Entry	:	Rutgers The State University of New Jersey - New Brunswick