| | Document Type | : | Latin Dissertation | Language of Document | : | English | Record Number | : | 54528 | Doc. No | : | TL24482 | Call number | : | 3319449 | Main Entry | : | Mohammad Sedighi | Title & Author | : | The physics of chromatin silencing: Bi-stability and front propagationMohammad Sedighi | College | : | Rutgers The State University of New Jersey - New Brunswick | Date | : | 2007 | Degree | : | Ph.D. | student score | : | 2007 | Page No | : | 86 | Abstract | : | A mean-field dynamical model of chromatin silencing in budding yeast is provided and the conditions giving rise to two states: one silenced and another un-silenced, is studied. Based on these conditions, the space of control parameters is divided into two distinct regions of mono-stable and bi-stable solutions (the bifurcation diagram). Then, considering both the discrete and continuous versions of the model, the formation of a stable boundary between the silenced and un-silenced areas on DNA is investigated. As a result, a richer phase diagram is provided. The dynamics of the boundary is also studied under different conditions. Consequently, assuming negative feedback due to possible depletion of silencing proteins, the model explains a paradoxical epigenetic behavior of yeast that happens under some mutation. A stochastic treatment of the model is also considered to verify the results of the mean-field approximation and also to understand the role of intrinsic noise at single cell level. This model could be used as a general guide to discuss chromatin silencing in many organisms. | Subject | : | Pure sciences; Biological sciences; Chromatin; Silencing; Bistability; Front propagation; Systems biology; Chromatin silencing; Physics; Biophysics; 0786:Biophysics; 0605:Physics | Added Entry | : | A. Sengupta | Added Entry | : | Rutgers The State University of New Jersey - New Brunswick |
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http://lib.clisel.com/site/catalogue/54528
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