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Document Type:Latin Dissertation
Language of Document:English
Record Number:54528
Doc. No:TL24482
Call number:‭3319449‬
Main Entry:Mohammad Sedighi
Title & Author:The physics of chromatin silencing: Bi-stability and front propagationMohammad Sedighi
College:Rutgers The State University of New Jersey - New Brunswick
Date:2007
Degree:Ph.D.
student score:2007
Page No:86
Abstract:A mean-field dynamical model of chromatin silencing in budding yeast is provided and the conditions giving rise to two states: one silenced and another un-silenced, is studied. Based on these conditions, the space of control parameters is divided into two distinct regions of mono-stable and bi-stable solutions (the bifurcation diagram). Then, considering both the discrete and continuous versions of the model, the formation of a stable boundary between the silenced and un-silenced areas on DNA is investigated. As a result, a richer phase diagram is provided. The dynamics of the boundary is also studied under different conditions. Consequently, assuming negative feedback due to possible depletion of silencing proteins, the model explains a paradoxical epigenetic behavior of yeast that happens under some mutation. A stochastic treatment of the model is also considered to verify the results of the mean-field approximation and also to understand the role of intrinsic noise at single cell level. This model could be used as a general guide to discuss chromatin silencing in many organisms.
Subject:Pure sciences; Biological sciences; Chromatin; Silencing; Bistability; Front propagation; Systems biology; Chromatin silencing; Physics; Biophysics; 0786:Biophysics; 0605:Physics
Added Entry:A. Sengupta
Added Entry:Rutgers The State University of New Jersey - New Brunswick