| | | Document Type | : | Latin Dissertation | | Language of Document | : | English | | Record Number | : | 54528 | | Doc. No | : | TL24482 | | Call number | : | 3319449 | | Main Entry | : | Mohammad Sedighi | | Title & Author | : | The physics of chromatin silencing: Bi-stability and front propagationMohammad Sedighi | | College | : | Rutgers The State University of New Jersey - New Brunswick | | Date | : | 2007 | | Degree | : | Ph.D. | | student score | : | 2007 | | Page No | : | 86 | | Abstract | : | A mean-field dynamical model of chromatin silencing in budding yeast is provided and the conditions giving rise to two states: one silenced and another un-silenced, is studied. Based on these conditions, the space of control parameters is divided into two distinct regions of mono-stable and bi-stable solutions (the bifurcation diagram). Then, considering both the discrete and continuous versions of the model, the formation of a stable boundary between the silenced and un-silenced areas on DNA is investigated. As a result, a richer phase diagram is provided. The dynamics of the boundary is also studied under different conditions. Consequently, assuming negative feedback due to possible depletion of silencing proteins, the model explains a paradoxical epigenetic behavior of yeast that happens under some mutation. A stochastic treatment of the model is also considered to verify the results of the mean-field approximation and also to understand the role of intrinsic noise at single cell level. This model could be used as a general guide to discuss chromatin silencing in many organisms. | | Subject | : | Pure sciences; Biological sciences; Chromatin; Silencing; Bistability; Front propagation; Systems biology; Chromatin silencing; Physics; Biophysics; 0786:Biophysics; 0605:Physics | | Added Entry | : | A. Sengupta | | Added Entry | : | Rutgers The State University of New Jersey - New Brunswick |
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http://lib.clisel.com/site/catalogue/54528
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