خط مشی دسترسیدرباره ماپشتیبانی آنلاین
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Document Type:Latin Dissertation
Language of Document:English
Record Number:55365
Doc. No:TL25319
Call number:‭3370933‬
Main Entry:Pattaraporn Vanachayangkul
Title & Author:Ammi visnaga L. for the prevention of urolithiasisPattaraporn Vanachayangkul
College:University of Florida
Date:2008
Degree:Ph.D.
student score:2008
Page No:117
Abstract:Urolithiasis is a clinical condition referred to as kidney stone disease. This disease is common and currently may affect many people in industrialized countries. Several factors can promote the formation of kidney stones such as dehydration, consumption of certain foods that contain high amount of calcium, oxalate or uric acid and some infectious diseases. Most people can develop kidney stones sometime in their lives and may pass stones through the urinary tract unnoticed. The stones usually composed mainly of calcium oxalate (CaOx). However, if the stone enlarges, it will obstruct the urinary system. Symptoms initially present with severe pain and if the stone damages the urinary tube, then blood can be excreted in the urine. The most effective treatment of kidney stones is extracorporeal shock wave lithotripsy (ESWL), but this treatment still has several disadvantages including high costs, the reoccurance of kidney stones and potential renal damage. Therefore, alternative medication with less side effects it is of great interest to investigate. Ammi visnaga L. or Khella (KE, Apiaceae) is traditionally used as treatment for kidney stones as a tea preparation from Egypt. KE is used to relieve the pain and help the stone pass through the ureter. On the basis of this consideration, KE was characterized and investigated for the preventive effect of kidney stone formation in our study. HPLC analysis was used to identify and quantify KE. In cell culture experiments, it was found that KE and its compounds protect cell damage from CaOx crystals. In addition, KE and its compounds prevented CaOx formation in stone forming rats by increasing the urinary pH and citrate concentration along with a decrease of urinary oxalate. The CaOx crystals deposition in the rat kidneys was significantly decreased in the group of rats receiving KE and its compounds. The pharmacokinetic study of visnagin was investigated and revealed that visnagin was a short half-life compound with complete absorption. In conclusion, results indicated that KE could be used as a preventive agent for kidney stone disease.
Subject:Health and environmental sciences; Urolithiasis; Ammi visnaga; Kidney stones; Herbal medicines; Pharmacology; Pharmacy sciences; 0572:Pharmacy sciences; 0419:Pharmacology
Added Entry:V. Butterweck
Added Entry:University of Florida