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Document Type:Latin Dissertation
Language of Document:English
Record Number:55624
Doc. No:TL25578
Call number:‭U593309‬
Main Entry:Emily D. Williams
Title & Author:Psychosocial factors related to cardiovascular disease risk in UK South Asian men and womenEmily D. Williams
College:University of London, University College London (United Kingdom)
Date:2008
Degree:Ph.D.
student score:2008
Page No:431
Abstract:The reasons for the heightened coronary heart disease (CHD) risk of South Asians (people from the Indian subcontinent) living in the United Kingdom (UK) are not well understood. Standard risk factors do not fully explain the heightened CHD risk, and although diabetes, insulin resistance and abdominal obesity are involved, other variables may also be relevant. This study tested the hypotheses that UK South Asians are exposed to greater psychosocial stress than European whites, and that psychosocial factors are associated with biological CHD risk in South Asians. 939 apparently healthy UK South Asian and 482 European white men and women, aged 35-75 years, were randomly selected from a larger study in West London. Psychosocial data were collected in questionnaire form. Potential biological mediators and subclinical CHD markers (coronary artery calcium) were also measured. Analyses showed that South Asians suffered significantly greater psychosocial adversity compared with UK whites, in terms of chronic stressors, psychological characteristics and social relationships. The South Asian group also had worse biological CHD risk profiles. Subgroup analyses by religious affiliation showed that Muslims were more disadvantaged on psychosocial, behavioural, and biological profiles than Hindus and Sikhs. Exploratory analyses identified possible psychosocial-biological associations, which might provide insight into the mechanisms through which psychosocial factors may influence CHD risk. This investigation is consistent with the possibility that psychosocial adversity contributes to heightened vulnerability to CHD in UK South Asians, and must be acknowledged when researchers and clinicians are addressing this issue.
Subject:(UMI)AAIU593309; Health and environmental sciences; Cardiovascular disease; United Kingdom; Epidemiology; 0766:Epidemiology
Added Entry:University of London, University College London (United Kingdom)