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" Blood Cells, Rheology, and Aging "
edited by Dieter Platt.
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BL
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| Record Number
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578289
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b407508
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| Main Entry
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Platt, Dieter.
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| Title & Author
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Blood Cells, Rheology, and Aging\ edited by Dieter Platt.
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| Publication Statement
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Berlin, Heidelberg :: Springer Berlin Heidelberg,, 1988.
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| ISBN
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9783642717901
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: 9783642717925
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| Contents
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Hemopoiesis as a Model for the 'Biological Clock'. -- Red Cell Membrane Skeleton: Assembly and Function. -- Red Cell Membrane Lipids and Aging -- Red Cell Membrane Proteins, Glycoproteins, and Aging -- The Effect of Host and Cell Age on the Rat Erythrocyte: Biochemical Aspects -- The Effect of Host and Cell Age on the Rat and Human Erythrocyte: Cellular and Immunologic Aspects -- Removal of Old and Abnormal Red Blood Cells from Circulation: Mechanical and Immunologic Mechanisms. -- Mechanism for Elimination of Senescent Red Blood Cells from Circulation -- The Influence of Piracetam on the Age-Dependent Rate of Phagocytosis (in the Isolated Perfused Rat Liver) -- Changes in Human Red Cell Mechanics During In Vivo Aging: Possible Influence on Removal of Senescent Cells -- Age-Related Physiologic and Molecular Changes in the Thymusx -- The Cellular Basis and Clinical Significance of Immune Senescence -- Regulation of the Immune and Nonimmune Aging Process by the Major Histocompatibility Complex -- Age-Related Morphologic Changes in Lymphocytes -- Receptor and Postreceptor Changes During Lymphocyte Aging -- Mechanism of Red Cell Aggregation -- Fluidity of Blood of Elderly Patients and Rheologic Therapies -- Hemostasis, Microcirculation, and Thrombophilia in the Aged -- Influence of Age, Sex, and Blood Group on Blood Coagulation -- Fibrinogen in the Aged - Functional and Structural Aspects.
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| Abstract
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In the third Erlangen-Nuremberg symposium on experimental geronto logy we discussed the effect of aging on blood cells and rheology. Most studies with red cells have been performed on humans, rats, and rabbits. All these erythrocytes have no nucleus; the cells are therefore a model in which new synthesis of proteins is impossible. All the processes are age dependent except for exchange with the plasma. Investigations of red cells have attracted attention because of the latter's availability in large quantities from biochemists, physiologists, immunologists, and micro scopists. We now have a relative abundance of data on the biochemical and immunologic composition as well as on the ultrastructure of the cells. The second topic under discussion at the symposium was the immune system and cell receptors. One of the most apparent features of aging of the organism is progressive dysregulation of the immune system. As a result, the incidence of infection, cancer, and autoimmune and immune complex diseases increases. While we have a lot of new data on the function and differentiation of lymphoid cells, we have little informa tion on lymphocyte receptors during the aging process. Rheologic studies reflect changes in red cell deformability and blood coagulation. The erythrocyte deformability influences blood flow in all parts of the circulation. The fluidity of the red cell membranes controls whole blood viscosity. During aging, there are significant alterations in blood coagulation and hemostasis. One of the best known modifications of blood co agulation is a typical thrombophilic tendency with aging.
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Medicine.
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Immunology.
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Allergy.
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Hematology.
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| Added Entry
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SpringerLink (Online service)
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