| Document Type
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BL
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| Record Number
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590714
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| Doc. No
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b419933
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| Main Entry
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Walsh, Christopher
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| Title & Author
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Antibiotics : : actions, origins, resistance /\ by Christopher Walsh
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| Page. NO
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x, 335 pages :: illustrations (some color) ;; 26 cm
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| ISBN
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1555812546
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: 9781555812546
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: 9781555818937 (pbk.)
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: 1555818935 (pbk.)
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| Bibliographies/Indexes
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Includes bibliographical references (pages 297-328) and index
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| Contents
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Antibiotics : initial concepts -- Introduction to major antibiotic classes and modes of action -- Antibiotics that act on cell wall biosynthesis -- Antibiotics that block bacterial protein biosynthesis -- Antibiotics that block DNA replication and repair : the Quinolones -- Other targets of antibacterial drugs -- Natural and producer immunity versus acquired resistance -- Enzymatic destruction or modification of the antibiotic by resistant bacteria -- Antibiotic resistance by efflux pumps -- Antibiotic resistance by replacement or modification of the antibiotic target -- Regulation of antibiotic biosynthesis in producer organisms -- Polyketide antibiotic biosynthesis : assembly line enzymology -- Enzymatic assembly lines for nonribosomal peptide antibiotics -- Biosynthesis of other classes of antibiotics -- New looks at targets -- New molecules -- Contexts and challenges for the use of new antibiotics
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| Abstract
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As antibiotics become deactivated through resistance and emerging bacterial diseases Christopher Walsh offers new insights into antibiotic modification and design. He shows how antibiotics work on targets and reviews recent strategies for finding innovative antibiotics to replace the last generation
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| Subject
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Antibiotics
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| Subject
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Drug resistance in microorganisms
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| Subject
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Anti-Bacterial Agents-- pharmacology
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| Subject
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Drug Resistance, Bacterial
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| Dewey Classification
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615/.329
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| LC Classification
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RM267.W357 2003
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| NLM classification
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2003 F-959
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QV 350W223a 2003
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