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" Analysis of aggregates and particles in protein pharmaceuticals / "
edited by Hanns-Christian Mahler, Wim Jiskoot
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BL
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| Record Number
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597940
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| Doc. No
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b427159
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| Title & Author
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Analysis of aggregates and particles in protein pharmaceuticals /\ edited by Hanns-Christian Mahler, Wim Jiskoot
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| Publication Statement
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Hoboken, N.J. :: Wiley,, c2012
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| Page. NO
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xvi, 443 p., [12] p. of plates :: ill. (some col.) ;; 25 cm
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| ISBN
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9780470497180 (cloth)
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: 0470497181 (cloth)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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The critical need for robust assays for quantitation and characterization of aggregates of therapeutic proteins -- Separation-based analytical methods for measuring protein aggregation -- Laser light scattering-based techniques used for the characterization of protein therapeutics -- Online detection methods and emerging techniques for soluble aggregates in protein pharmaceuticals -- Analytical methods to measure subvisible particulates -- Detection of visible particles in parenteral products -- Characterization of aggregates and particles using emerging techniques -- Ultraviolet absorption spectroscopy -- Fluorescence spectroscopy to characterize protein aggregates and particles -- Infrared spectroscopy to characterize protein aggregates -- Raman microscopy for characterization of particles -- Microscopic methods for particle characterization in protein pharmaceuticals -- Comparison of methods for soluble aggregate detection and size characterization -- Protein purification and its relation to protein aggregation and particles -- Formulation development and its relation to protein aggregation and particles
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| Subject
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Protein drugs-- Analysis
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Pharmaceutical chemistry
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Pharmaceutical Preparations-- analysis
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Chemistry Techniques, Analytical-- methods
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Proteins-- pharmacokinetics
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| Dewey Classification
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615.1/9
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| LC Classification
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RS431.P75A533 2012
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| NLM classification
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2012 D-884
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QV 25
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| Added Entry
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Mahler, Hanns-Christian
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Jiskoot, Wim
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