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" Drug targeting "
edited by G.E. Francis and Cristina Delgado.
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BL
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| Record Number
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599931
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| Doc. No
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b429150
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| Title & Author
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Drug targeting : strategies, principles, and applications /\ edited by G.E. Francis and Cristina Delgado.
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| Publication Statement
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Totowa, N.J. :: Humana Press,, c2000.
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| Series Statement
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Methods in molecular medicine ;; 25
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| Page. NO
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x, 318 p. :: ill.
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| ISBN
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089603531X (alk. paper)
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: 9780896035317 (alk. paper)
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Pt.1. Strategies -- Chemical construction of immunotoxins -- Construction of ribonuclease-antibody conjugates for selective cytotoxicity -- Intracellular targeting using bispecific antibodies -- Antibody conjugation methods for active targeting of liposomes -- Folate as a targeting device for proteins utilizing folate receptor-mediated endocytosis -- Preparation of recombinant RNase single-chain antibody fusion proteins -- Pt.2. Theoretical aspects -- Practical considerations in the exploitation of passive tumor targeting -- Effect of dose, molecular size, and binding affinity on uptake of antibodies -- Inhibition of tumor blood flow -- Pt.3. Applications -- Targeting in myocardial infarction -- Targeting HIV-infected cells -- Making fusion toxins to targetleukemia and lymphoma -- Antibody-bearing liposomes as chloroquine vehicles in treatment of murine malaria -- Immunotargeting of catalase to the pulmonary vascular endothelium -- Targeted gene transfer: a practical guide based on experience with lipid-based plasmid delivery systems.
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| Subject
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Drug delivery systems.
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| Subject
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Drug carriers (Pharmacy)
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| Added Entry
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Francis, G. E.
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Delgado, Cristina.
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