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" Apoptosis, senescence, and cancer "
edited by David A. Gewirtz, Shawn E. Holt, Steven Grant.
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BL
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| Record Number
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602543
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| Doc. No
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b431762
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| Title & Author
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Apoptosis, senescence, and cancer\ edited by David A. Gewirtz, Shawn E. Holt, Steven Grant.
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| Edition Statement
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2nd ed.
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| Publication Statement
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Totowa, N.J. :: Humana Press,, c2007.
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| Series Statement
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Cancer drug discovery and development
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| Page. NO
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xvii, 599 p. :: ill. ;; 26 cm.
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| ISBN
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1588295273 (alk. paper)
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: 9781588295279 (alk. paper)
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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The intrinsic pathway of apoptosis -- The extrinsic pathway of apoptosis -- Evaluating the importance of apoptosis and other determinants of cell death and survival -- Mitotic catastrophe -- Autophagy and autophagic cell death -- Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis -- Structure and function of the telomere -- Overview of senescence -- Contributions of telomerase to tumorigenesis -- The role of telomeres in genomic instability -- Overview of the DNA damage checkpoint: ATM and ATR -- Interactions between myc- and cyclin-dependent kinase inhibitors in cancer -- Interplay between [gamma]H2AX and 53BP1 pathways in DNA double-strand break repair response -- DNA-dependent protein kinase in repair, apoptosis, telomere maintenance, and chemotherapy -- Resistance/signaling pathways -- Ceramide and multidrug resistance -- Chemo- and radiosensitization through inhibition of PI3K/Akt signaling -- The advancement of epidermal growth factor receptor inhibitors in cancer therapy -- Antimetabolites -- Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes -- Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? -- The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs -- Contributions of apoptosis and senescence to cytotoxicity produced by microtubule-stabilizing agents -- Tyrosine kinase inhibitors -- Monoclonal antibodies in lymphomas -- Role of apoptosis in anti-angiogenic cancer therapies -- Photodynamic therapy-induced apoptosis -- Modulation of TRAIL signaling for cancer therapy.
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| Subject
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Apoptosis.
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Cancer cells-- Growth-- Regulation.
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Cancer-- Chemotherapy.
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Cancer-- Radiotherapy.
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| Added Entry
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Gewirtz, David A.
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Grant, Steven.
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Holt, Shawn E.
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