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" Apoptosis, senescence and cancer / "
edited by David A. Gewirtz, Shawn E. Holt, Steven Grant
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BL
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| Record Number
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602544
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| Doc. No
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b431763
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| Title & Author
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Apoptosis, senescence and cancer /\ edited by David A. Gewirtz, Shawn E. Holt, Steven Grant
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| Edition Statement
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2nd ed
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| Publication Statement
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Totowa, N.J. :: Humana Press,, 2007
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| Series Statement
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Cancer drug discovery and development
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| Page. NO
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xvii, 599 p. :: ill. ;; 26 cm
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| ISBN
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1588295273 (hbk.)
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: 9781588295279 (hbk.)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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The intrinsic pathway of apoptosis. -- The extrinsic pathway of apoptosis. -- Evaluating the importance of apoptosis and other determinants of cell death and survival. -- Mitotic catastrophe. -- Autophagy and autophagic cell death. -- Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis. -- Structure and function of the telomere. -- Overview of senescence. -- Contributions of telomerase to tumorigenesis. -- The role of telomeres in genomic instability. -- Overview of the DNA damage checkpoint: ATM and ATR. -- Interactions between myc- and cyclin-dependent kinase inhibitors in cancer. -- Interplay between [gamma]H2AX and 53BP1 pathways in DNA double-strand break repair response. -- DNA-dependent protein kinase in repair, apoptosis, telomere maintenance, and chemotherapy. -- Resistance/signaling pathways. -- Ceramide and multidrug resistance. -- Chemo- and radiosensitization through inhibition of PI3K/Akt signaling. -- The advancement of epidermal growth factor receptor inhibitors in cancer therapy. -- Antimetabolites. -- Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes. -- Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? -- The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs. -- Contributions of apoptosis and senescence to cytotoxicity produced by microtubule-stabilizing agents. -- Tyrosine kinase inhibitors. -- Monoclonal antibodies in lymphomas. -- Role of apoptosis in anti-angiogenic cancer therapies. -- Photodynamic therapy-induced apoptosis. -- Modulation of TRAIL signaling for cancer therapy
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Cancer cells-- Growth-- Regulation
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Cancer-- Chemotherapy
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Cancer-- Radiotherapy
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Apoptosis
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Neoplasms-- drug therapy
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Neoplasms-- radiotherapy
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Apoptosis
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Cell Aging
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| Added Entry
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Gewirtz, David A
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Holt, Shawn E
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Grant, Steven
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