| Document Type
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BL
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| Record Number
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603246
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| Doc. No
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b432465
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| Title & Author
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Developmental and reproductive toxicology : : a practical approach /\ edited by Ronald D. Hood
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| Edition Statement
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3rd ed
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| Publication Statement
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London ;New York :: Informa Healthcare,, 2012
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| Page. NO
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xiii, 856 p. :: ill. ;; 26 cm
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| ISBN
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9781841847771 (hb)
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: 1841847771 (hb)
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: 9781841848211 (e-ISBN)
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: 1841848212 (e-ISBN)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Section I. Principles and Mechanisms: Principles of developmental toxicology revisited -- Experimental approaches to evaluate mechanisms of developmental toxicity -- Experimental approaches to evaluate mechanisms of reproductive toxicity -- Maternally-mediated effects on development -- Paternally-mediated effects on development -- Comparative gestational milestones in vertebrate development -- Section II. Testing Principles and Methodology: Developmental toxicity testing - methodology -- Reproductive toxicity testing - methodology -- Significance, reliability and interpretation of developmental and reproductive toxicity study findings -- Nonclinical juvenile toxicity testing -- Neurobehavioral testing for developmental toxicity --The U.S. EPA Endocrine Disruptor Screening Program: the tier 1 screening battery -- In vitro screening methods for developmental toxicology -- Approaches for evaluation mode of action --
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Functional genomics and proteomics in developmental and reproductive toxicology -- Nonhuman primates as preclinical models for developmental and reproductive toxicity evaluation -- Developmental and reproductive safety assessment of biopharmaceuticals -- Developmental immunotoxicity testing -- Developmental and reproductive safety testing of vaccines -- Use of toxicokinetics in developmental and reproductive toxicology -- Understandiing statistics in developmental and reproductive toxicology -- Quality concerns for reproductive and developmental toxicology studies -- Predictive modeling and computational toxicology -- Critical evaluation of current developmental toxicity testing strategies - A case of babies and their bathwater -- Section III. Risk Assessment and Regulatory Guidance: Perspectives on the developmental and reproductive toxicity guidelines -- Human studies - epidemiologic techniques in developmental and reproductive toxicology -- Developmental and reproductive toxicity risk assessment for environmental agents -- Perspectives in risk assessment - Drug and vaccine safety -- Developmental and reproductive toxicity evaluation under the European Union REACH regulations -- Appendix: Terminology of developmental abnormalities in common laboratory mammals (version 2)
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| Abstract
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"Developmental and Reproductive Toxicology: A Practical Approach, Third Edition is a guide for developmental and reproductive toxicologists. Completely revised and updated, this new edition new chapters covers genomics/proteomics, endocrine disruptors, testing for male and female reproductive toxicity, data interpretation in developmental and reproductive toxicity testing, nonclinical juvenile toxicity testing, and the FDA perspective on risk assessment. It includes material on postnatal developmental milestones and extensive glossaries of developmental defect terminology. Practical and informative, the book bridges the gap between theory and application. It contains insights gained from hands-on experience and gathers information scattered throughout the literature, along with previously unpublished information, into one reference"--Provided by publisher
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| Subject
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Developmental toxicology, Handbooks, manuals, etc
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Reproductive toxicology, Handbooks, manuals, etc
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Abnormalities, Drug-Induced
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Embryonic Development-- drug effects
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Fetus-- drug effects
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Reproduction-- drug effects
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| Subject
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Teratogens
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| Subject
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Toxicity Tests
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| Dewey Classification
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615.9
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| LC Classification
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RA1224.2.H36 2012
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| NLM classification
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QS 679D4886 2012
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| Added Entry
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Hood, Ronald D
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