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" Metabolism, pharmacokinetics, and toxicity of functional groups : "
edited by Dennis A. Smith
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BL
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| Record Number
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603567
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| Doc. No
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GBB028696b432786
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| Title & Author
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Metabolism, pharmacokinetics, and toxicity of functional groups : : impact of the building blocks of medicinal chemistry in ADMET /\ edited by Dennis A. Smith
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| Publication Statement
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Cambridge, [England] :: Royal Society of Chemistry,, 2010
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| Series Statement
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RSC drug discovery series,; no. 1
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| Page. NO
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xiv, 530 p. :: ill. ;; 25 cm
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| ISBN
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9781849730167 (hbk.)
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: 1849730164 (hbk.)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Drugs and their structural motifs -- ADMET for the medicinal chemist -- Carboxylic acids and their bioisosteres -- Primary, secondary, and tertiary amines and their isosteres -- Sulfonamide as an essential functional group in drug design -- Influence of aromatic rings on ADME properties of drugs -- Influence of heteroaromatic rings on ADME properties -- Peptidomimetics and peptides as drugs: motifs incorporated to enhance drug characteristics -- Pharmacokinetics and metabolism of compounds that mimic enzyme transition states -- Alcohols and phenols: absorption, distribution, metabolism, and excretion -- Future targets and chemistry and ADME needs
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| Subject
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Pharmacokinetics
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Chemistry, Pharmaceutical-- methods
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Pharmaceutical Preparations-- metabolism
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Pharmacokinetics
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Drugs-- Metabolism
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Functional groups
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Toxicity testing
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| Dewey Classification
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615.704
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| LC Classification
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RM301.5.M483 2010
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| NLM classification
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2010 F-306
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QV 38
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| Added Entry
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Smith, Dennis A
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| Added Entry
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Royal Society of Chemistry (Great Britain)
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