| Document Type
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BL
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| Record Number
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603572
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| Doc. No
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b432791
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| Title & Author
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New horizons in predictive toxicology : : current status and application /\ edited by Alan G. E. Wilson
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| Publication Statement
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Cambridge :: Royal Society of Chemistry,, c2012
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| Series Statement
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RSC drug discovery series,; no. 12
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| Page. NO
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xxix, 702 p. :: ill. (some col.) ;; 24 cm
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| ISBN
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9781849730518
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: 1849730512
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Acknowledgements -- Chapter 1. Introduction and overview / Alan G. E. Wilson -- Chapter 2. In silico tools for toxicity prediction / Mark T. D. Cronin -- Chapter 3. Development of an evaluation support system for estimating repeated-dose toxicity of chemicals based on chemical structure / Makoto Hayashi and Yuki Sakuratani -- Chapter 4. Towards a common regulatory framework for computational toxicology: current status and future perspectives / Andrew P. Worth and Aleksandra Mostrag-Szlichtyng -- Chapter 5. Information, informatics and modeling in predictive toxicology / Scott Boyer, Daniel Muthas and Nigel Greene -- Chapter 6. Cellular stress and in vitro predictive toxicology / Xuemei Liu, Jeffrey A. Kramer and Alan G. E. Wilson -- Chapter 7. In vitro genotoxicity / John J. Nicolette ... [et al.] -- Chapter 8. Cardiac toxicity prediction: to simplify, or to integrate, that is the question / Vivek J. Kadambi, Colleen Synan and Katherine Brewer -- Chapter 9. In vitro approaches for determining liver-specific toxicity of new drug candidates / James M. McKim Jr. -- Chapter 10. Human-based in vitro experimental systems for the assessment of human-specific adverse drug effects: scientific concepts, current applications and promising approaches / Albert P. Li -- Chapter 11. Pathways of organ injury to define human response in organotypic cultures / Alison E. M. Vickers -- Chapter 12. Predicting drug-induced mitochondrial dysfunction / Sashi Nadanaciva and Yvonne Will -- Chapter 13. Non-clinical models for the evaluation of mechanisms of toxicity / Jeffrey A. Kramer -- Chapter 14. In vivo approaches to predictive toxicology using zebrafish / Michael T. Simonich, Jill A. Franzosa and Robert L. Tanguay -- Chapter 15. In vivo genetic toxicology: application to cancer risk assessment / Michael J. Schlosser and Christopher S. Farabaugh -- Chapter 16. Predicting hepatotoxicity in vivo / Timothy Maziasz -- Chapter 17. Immunotoxicity testing / Thomas T. Kawabata ... [et al.] -- Chapter 18. In vitro developmental models and their applications in teratology research / Karen Augustine-Rauch, Julieta M. Panzica-Kelly and Cindy X. Zhang -- Chapter 19. Role and status of bridging biomarkers in predictive toxicology / William B. Mattes -- Chapter 20. Renal toxicity / K. Nasir M. Khan, Gordon C. Hard and Zaher A. Radi -- Chapter 21. Metabolism-based toxicology prediction / F. Peter Guengerich -- Chapter 22. Impact of drug transporters in the pharmacological and adverse reactions of drugs / Hiroyuki Kusuhara, Kazuya Maeda and Yuichi Sugiyama -- Chapter 23. Toxicokinetics / Dennis A. Smith -- Chapter 24. The role of computational systems biology models in toxicity testing in the 21st century: an example with predictive multi-scale models of the liver / Sudin Bhattacharya ... [et al.] -- Chapter 25. Animal models of idiosyncratic, drug-induced liver injury / Christine M. Dugan, Patricia E. Ganey and Robert A. Roth -- Subject index
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| Abstract
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"In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including the in silico, in vitro and in vivo approaches being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen our ability to predict the risks posed by industrial and pharmaceutical chemicals in humans. Extensive information on the use of current animal models used for various toxicities and target-mediated toxicities is included. Also discussed are the recently introduced regulatory initiatives."-Publisher's description
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| Subject
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Toxicology-- Mathematical models
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| Subject
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Toxicology-- Computer simulation
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Toxicology-- Risk assessment
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Toxicology-- Simulation methods
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Toxicology-- Animal models
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| Subject
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Toxicity testing-- In vitro
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| Subject
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Toxicity testing-- In vivo
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| LC Classification
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RA1199.4.M37N49 2012
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| Added Entry
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Wilson, Alan G. E
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| Added Entry
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Royal Society of Chemistry (Great Britain)
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