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BL
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| Record Number
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603964
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b433183
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| Title & Author
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Apolipoprotein mimetics in the management of human disease /\ G.M. Anantharamaiah, Dennis Goldberg, editors
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| Page. NO
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1 online resource :: illustrations (mostly color)
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| ISBN
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9783319173504
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: 3319173502
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9783319173498
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3319173499 (print)
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9783319173498 (print)
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| Bibliographies/Indexes
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Includes bibliographical references
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| Contents
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Preface; Abbreviations; Contents; Introduction; The Structure and Function of Apolipoprotein Mimetic Peptides; Bibliography; The Editors; HDL and the Amphipathic Helix; Discovery, Isolation, and Characterization of HDL; Early History of HDL Structure; Discovery of the Amphipathic Helix: An Untold Story; The Amphipathic Helix and HDL; Current History of HDL Structure; Current Thoughts on the Biomedical Implications of HDL; What Are Peptide Mimetics and Should I Care?; References; ApoA-I Mimetic Peptides: A Review of the Present Status
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ApoA-I Mimetic Peptides Were Designed to Mimic a Plasma Apolipoprotein The Peptides Were Effective in a Large Number of Animal Models of Disease; The 4F Peptide Was Tested in Human Clinical Trials; Reconciling the Divergent Results from the Clinical Trials; Overcoming the Barrier of the High Cost of Production of Chemically Synthesized ApoA-I Mimetic Peptides; Determining the Mechanism of Action of Oral ApoA-I Mimetic Peptides; Other Peptides; Conclusions; References; Apolipoprotein Mimetic Peptides for Stimulating Cholesterol Efflux; Introduction; Reverse Cholesterol Transport Pathway
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Apolipoprotein Mimetic PeptidesESP24218 Peptide; D-4F Peptide; L-4F Peptide; Retroinverso Peptides; 5A Peptide; ATI-5261 Peptide; Summary; References; ApoA-I Mimetic Peptides and Diabetes; Introduction; 4F Background; 4F and Diabetes; Conclusion; References; Apolipoprotein A-I Mimetic Peptides in Mouse Models of Cancer; Introduction; Inflammation and Lipoproteins in Cancer; ApoA-I and Ovarian Cancer; ApoA-I Mimetic Peptides as Cancer Therapeutics; ApoA-I Mimetic Peptides and Colon Cancer; Conclusions; References
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Effects of ApoA-I Mimetic Peptide L-4F in LPS-Mediated InflammationIntroduction; LPS and Sepsis; HDL and LPS; ApoA-I and Sepsis; ApoA-I Mimetic Peptides 18A and 4F; ApoA-I Mimetic Peptide L-4F and LPS; ApoA-I Mimetic Peptide L-4F in Polymicrobial Septic Models; Efficacy of L-4F in Different Models of Atherosclerosis and Metabolic Syndrome (Diabetes) Could Be in Part Accounted for by Its Anti-endotoxin Property; References; Apolipoprotein Mimetics in the Amelioration of Respiratory Inflammation; Introduction; Genetic Deletion of ApoA-I; 4F Inhibits Airway Inflammation
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Potential Mechanisms of Action Other Apolipoprotein Mimetics That Modulate Airway Inflammation; Novel Apolipoprotein Mimetics; References; Regulation of Macrophage Polarity by HDL, Apolipoproteins, and Apolipoprotein Mimetic Peptides; Introduction; Macrophage Polarization; Macrophage Heterogeneity and Atherosclerosis; HDL Composition and Function; Dysfunctional HDL; HDL-Associated S1P and Macrophage Phenotype; ABCA1 and Macrophage Polarization; HDL, Activating Transcription Factor, and Macrophage Polarization; Apolipoprotein A-I Mimetic Peptide Design
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| Abstract
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This comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. The book consists of 11 chapters all written by leading scientists from well-reputed laboratories in the USA. After an introduction by Dr. Godfrey Getz, Professor of Medicine at the University of Chicago and the Associate Editor of the Journal Lipid Research, the book presents a narration of how a theory can lead to the discovery o
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| Subject
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Apolipoproteins.
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High density lipoproteins.
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Peptides.
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Lipids-- Metabolism.
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Biochemistry.
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Cardiology.
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Medicine.
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| Dewey Classification
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572/.6
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| LC Classification
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QP99.3.A65
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| Added Entry
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Anantharamaiah, G. M., (Gattadahalli Manjunath),1947-
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Goldberg, Dennis Ian,1948-
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Ohio Library and Information Network.
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