| Document Type
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BL
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| Record Number
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604156
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| Doc. No
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GBB275674b433375
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| Title & Author
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Reactive drug metabolites /\ Amit S. Kalgutkar ... [et al.]
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| Publication Statement
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Weinheim :: Wiley-VCH,, c2012
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| Series Statement
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Methods and principles in medicinal chemistry ;; v. 55
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| Page. NO
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xvi, 385 p. :: ill. ;; 25 cm
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| ISBN
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9783527330850 (hbk. : alk. paper)
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: 3527330852 (hbk. : alk. paper)
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9783527655779 (ePDF)
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9783527655748 (eBook)
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3527655743 (eBook)
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9783527655755 (mobi)
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3527655751 (mobi)
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9783527655748 (oBook)
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3527655743 (oBook)
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Origin and historical perspective on reactive metabolites -- Role of reactive metabolites in genotoxicity -- Bioactivation and inactivation of cytochrome P450 and other drug-metabolizing enzymes -- Role of reactive metabolites in drug-induced toxicity - the tale of acetaminophen, halothane, hydralazine, and tienilic acid -- Pathways of reactive metabolite formation with toxicophores/-structural alerts -- Intrinsically electrophilic compounds as a liability in drug discovery -- Role of reactive metabolites in pharmacological action -- Retrospective analysis of structure-toxicity relationships of drugs -- Bioactivation and natural products -- Experimental approaches to reactive metabolite detection -- Case studies on eliminating/reducing reactive metabolite formation in drug discovery -- Structural alert and reactive metabolite analysis for the top 200 drugs in the US market by prescription -- Mitigating toxicity risks with affinity labeling drug candidates -- Dealing with reactive metabolite-positive compounds in drug discovery -- Managing IADRs - a risk-benefit analysis
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| Subject
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Drugs-- Toxicology
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Drug-Related Side Effects and Adverse Reactions
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| Subject
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Pharmaceutical Preparations-- metabolism
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| Subject
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Drug Discovery
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| Dewey Classification
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615.704
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| LC Classification
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RA1238.R43 2012
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| NLM classification
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W1ME9613H v.55 2012
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QV 600
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| Added Entry
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Kalgutkar, Amit S.,1965-
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