| Document Type
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BL
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| Record Number
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604177
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| Doc. No
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b433396
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| Title & Author
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Therapeutic proteins : : strategies to modulate their plasma half-lives /\ edited by Roland Kontermann.
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| Series Statement
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Methods and principles in medicinal chemistry ;; v. 48
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| Page. NO
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1 online resource (xviii, 354 pages) :: illustrations (some color).
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| ISBN
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9783527644827 (electronic bk.)
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: 3527644822 (electronic bk.)
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: 9783527644797 (electronic bk.)
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: 3527644792 (electronic bk.)
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: 9783527644780 (electronic bk.)
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: 3527644784 (electronic bk.)
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: 9783527644803 (electronic bk.)
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: 3527644806 (electronic bk.)
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9783527328499
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Front Matter -- General Information. Half-Life Modulating Strategies : An Introduction / Roland E Kontermann -- Pharmacokinetics and Half-Life of Protein Therapeutics / Bernd Meibohm -- Half-Life Extension through Chemical and Post-Translational Modifications. Half-Life Extension through PEGylation / Simona Jev(evar, Menci Kunstelj -- Half-Life Extension of Therapeutic Proteins via Genetic Fusion to Recombinant PEG Mimetics / Uli Binder, Arne Skerra -- Half-Life Extension through -Glycosylation / Fuad Fares -- Polysialic Acid and Polysialylation to Modulate Antibody Pharmacokinetics / Antony Constantinou, Chen Chen, Mahendra P Deonarain -- Half-Life Extension through HESylationʼ / Thomas Hey, Helmut Knoller, Peter Vorstheim -- Half-Life Modulation Involving Recycling by the Neonatal Fc Receptor. The Biology of the Neonatal Fc Receptor (FcRn) / Jonghan Kim -- Half-Life Extension by Fusion to the Fc Region / Jalal A Jazayeri, Graeme J Carroll -- Monomeric Fc Fusion Technology: An Approach to Create Long-Lasting Clotting Factors / Jennifer A Dumont, Xiaomei Jin, Robert T Peters, Alvin Luk, Glenn F Pierce, Alan J Bitonti -- The Diverse Roles of FcRn: Implications for Antibody Engineering / E Sally Ward, Raimund J Ober -- Half-Life Extension by Fusion to Recombinant Albumin / Hubert J Metzner, Thomas Weimer, Stefan Schulte -- AlbudAb9 Technology Platform6Versatile Albumin Binding Domains for the Development of Therapeutics with Tunable Half-Lives / Christopher Herring, Oliver Schon -- Half-Life Extension by Binding to Albumin through an Albumin Binding Domain / Fredrik Y Frejd -- Half-Life Extension by Binding to Albumin through Small Molecules / Sabrina Trussel, Joerg Scheuermann, Dario Neri -- Half-Life Extension with Pharmaceutical Formulations. Half-Life Extension with Pharmaceutical Formulations: Liposomes / Astrid Hartung, Gerd Bendas -- Half-Life Extension with Pharmaceutical Formulations: Nanoparticles by the Miniemulsion Process / Katharina Landfester, Anna Musyanovych, Volker Maĩlnder -- Index
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| Subject
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Protein drugs-- Design.
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| Subject
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Proteins-- Therapeutic use.
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| Dewey Classification
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615.3
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| LC Classification
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RS431.P75T44 2012
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| NLM classification
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QV 744V819 2011
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| Added Entry
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Kontermann, Roland,1961-
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| Added Entry
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Ohio Library and Information Network.
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Wiley Online Library (Online service)
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