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" Thymic development and selection of T Lymphocytes / "
Thomas Boehm, Yousuke Takahama, editors
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BL
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| Record Number
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605895
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| Doc. No
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b435114
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| Title & Author
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Thymic development and selection of T Lymphocytes /\ Thomas Boehm, Yousuke Takahama, editors
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| Series Statement
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Current Topics in Microbiology and Immunology,; volume 373
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| Page. NO
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1 online resource (vii, 132 pages) :: illustrations (some color)
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| ISBN
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9783642402524
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: 3642402526
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9783642402517
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: 3642402518
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: 9783642402517
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| Notes
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Includes index
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| Bibliographies/Indexes
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Includes bibliographical references and index
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| Contents
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Development and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function -- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes
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| Abstract
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The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity
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| Subject
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T cells
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Thymus-- Growth
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T-Lymphocytes
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Thymus Gland-- growth and development
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| LC Classification
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QR185.8.T2
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| Added Entry
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Boehm, T. L. J., (Thomas L. J.),1956-
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Takahama, Yousuke
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Ohio Library and Information Network
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