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" Drug repositioning "
edited by Michael J. Barratt, Donald Frail.
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BL
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| Record Number
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619222
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dltt
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| Title & Author
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Drug repositioning : bringing new life to shelved assets and existing drugs /\ edited by Michael J. Barratt, Donald Frail.
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| Publication Statement
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Hoboken, N. J. :: John Wiley & Sons,, c2012.
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| ISBN
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9780470878279
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: 0470878274
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9781118274408
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1118274407
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| Bibliographies/Indexes
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Includes bibliographical references and index.
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| Contents
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Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison -- Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt -- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller -- Regulatory considerations and strategies for drug repositioning / Ken Phelps -- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb -- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.] -- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.] -- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee -- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume -- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.] -- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong -- Drug repositioning efforts by non-profit foundations -- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark -- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.
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Drug development.
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Drug development.
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Drug Repositioning.
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Computational Biology-- methods.
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Drug Industry-- economics.
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Pharmaceutical Preparations-- economics.
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| Added Entry
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Barratt, Michael J.
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Frail, Donald.
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Wiley Online Library (Online service)
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