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" DNA methylation and complex human disease / "
Michel Neidhart
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BL
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| Record Number
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622464
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dltt
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| Main Entry
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Neidhart, Michel
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| Title & Author
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DNA methylation and complex human disease /\ Michel Neidhart
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| Page. NO
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xv, 529 pages :: illustrations ;; 24 cm
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| ISBN
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9780124201941
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: 0124201946
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Includes bibliographical references and index
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| Contents
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DNA methylation : introduction -- DNA methylation and epigenetic biomarkers in cancer -- DNA methylation and epigenetic biomarkers in non-neoplastic diseases -- DNA methylation and environmental factors -- DNA methylation and epidemiology -- DNA methylation and viral infections -- DNA methylation and cancer -- DNA methylation in breast and ovarian carcinomas -- DNA methylation in acquired drug resistance -- DNA methylation and endocrinology -- DNA methylation in metabolic diseases -- DNA methylation in pituitary diseases -- DNA methylation and development -- DNA methylation in growth retardation -- DNA methylation in cardiology -- DNA methylation and neurology -- DNA methylation in psychiatric diseases -- DNA methylation in cellular mechanisms of neurodegeneration -- DNA methylation and autoimmunity -- DNA methylation in lymphocyte development -- DNA methylation in stem cell diseases -- DNA methylation and rheumatology -- DNA methylation in synovial fibroblasts -- DNA methylation in osteoporosis -- Epigenetic therapies -- Demethylating agents -- Methyl donors -- Methylome analysis of complex diseases -- Methylome analysis in cancer -- Methylome analysis in non-neoplastic disease -- Outlook
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| Abstract
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Reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. this volume includes many pertinent advances in disease-bearing research, including therapies and the possibility of using methyl donors. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis. The author also presents the importance of high-throughput methylome analysis, as well as the advantages of DNA methylation as a biomarker over other molecular processes. An excellent resource for basic biology and translational researchers interested in developmental biology, genetics health genomics, epigenesis in complex disease, and therapeutic possibilities. Developmental biologists, geneticists, biotechnologists, and epidemiologists also have much to gain from this specialized and focused volume
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DNA-- Methylation
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Medical genetics
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DNA Methylation
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| Dewey Classification
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572.8/6
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| LC Classification
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QP624.5.M46N45 2016
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